Internalization of glimepiride and glibenclamide in the pancreatic B-cell

G. Marynissen; G. Smets; G. Klöppel; L. Gerlache; W. J. Malaisse

doi:10.1007/BF00572555

Internalization of glimepiride and glibenclamide in the pancreatic B-cell

G. Marynissen, G. Smets, G. Klöppel, L. Gerlache, W. J. Malaisse

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

Original language	English
Pages (from-to)	113-114
Number of pages	2
Journal	Acta Diabetologica
Volume	29
Issue number	2
DOIs	https://doi.org/10.1007/BF00572555
State	Published - Jun 1992
Externally published	Yes

Keywords

Glibenclamide
Glimepiride
Pancreatic islets

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00572555

Cite this

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title = "Internalization of glimepiride and glibenclamide in the pancreatic B-cell",

abstract = "When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.",

keywords = "Glibenclamide, Glimepiride, Pancreatic islets",

author = "G. Marynissen and G. Smets and G. Kl{\"o}ppel and L. Gerlache and Malaisse, {W. J.}",

year = "1992",

month = jun,

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journal = "Acta Diabetologica",

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T1 - Internalization of glimepiride and glibenclamide in the pancreatic B-cell

AU - Marynissen, G.

AU - Smets, G.

AU - Klöppel, G.

AU - Gerlache, L.

AU - Malaisse, W. J.

PY - 1992/6

Y1 - 1992/6

N2 - When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

AB - When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

KW - Glibenclamide

KW - Glimepiride

KW - Pancreatic islets

UR - http://www.scopus.com/inward/record.url?scp=0000697666&partnerID=8YFLogxK

U2 - 10.1007/BF00572555

DO - 10.1007/BF00572555

M3 - Article

AN - SCOPUS:0000697666

SN - 0940-5429

VL - 29

SP - 113

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JO - Acta Diabetologica

JF - Acta Diabetologica

IS - 2

ER -

Internalization of glimepiride and glibenclamide in the pancreatic B-cell

Abstract

Keywords

UN SDGs

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