Interleukin 6‐induced differentiation of a human B cell line into IgM‐secreting plasma cells is mediated by c‐fos

Dieter Körholz; Stefan Gerdau; Jürgen Enczmann; Norbert Zessack; Stefan Burdach

doi:10.1002/eji.1830220248

Interleukin 6‐induced differentiation of a human B cell line into IgM‐secreting plasma cells is mediated by c‐fos

Dieter Körholz
, Stefan Gerdau
, Jürgen Enczmann
, Norbert Zessack
, Stefan Burdach

Medical Faculty and University Hospital Düsseldorf

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The role of the protooncogene c‐fos in interleukin (IL) 6‐induced B cell differentiation was assessed. Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c‐fos sense mRNA expression. The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c‐fos significantly inhibited IL 6‐induced IgM production by SKW 6.4 cells (p < 0.001), whereas control oligonucleotides had no inhibitory effect. These results indicate that activation of c‐fos is involved in IL 6‐induced differentiation of SKW 6.4 cells into IgM‐secreting cells.

Original language	English
Pages (from-to)	607-610
Number of pages	4
Journal	European Journal of Immunology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/eji.1830220248
State	Published - Feb 1992
Externally published	Yes

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title = "Interleukin 6‐induced differentiation of a human B cell line into IgM‐secreting plasma cells is mediated by c‐fos",

abstract = "The role of the protooncogene c‐fos in interleukin (IL) 6‐induced B cell differentiation was assessed. Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c‐fos sense mRNA expression. The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c‐fos significantly inhibited IL 6‐induced IgM production by SKW 6.4 cells (p < 0.001), whereas control oligonucleotides had no inhibitory effect. These results indicate that activation of c‐fos is involved in IL 6‐induced differentiation of SKW 6.4 cells into IgM‐secreting cells.",

author = "Dieter K{\"o}rholz and Stefan Gerdau and J{\"u}rgen Enczmann and Norbert Zessack and Stefan Burdach",

year = "1992",

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T1 - Interleukin 6‐induced differentiation of a human B cell line into IgM‐secreting plasma cells is mediated by c‐fos

AU - Körholz, Dieter

AU - Gerdau, Stefan

AU - Enczmann, Jürgen

AU - Zessack, Norbert

AU - Burdach, Stefan

PY - 1992/2

Y1 - 1992/2

N2 - The role of the protooncogene c‐fos in interleukin (IL) 6‐induced B cell differentiation was assessed. Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c‐fos sense mRNA expression. The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c‐fos significantly inhibited IL 6‐induced IgM production by SKW 6.4 cells (p < 0.001), whereas control oligonucleotides had no inhibitory effect. These results indicate that activation of c‐fos is involved in IL 6‐induced differentiation of SKW 6.4 cells into IgM‐secreting cells.

AB - The role of the protooncogene c‐fos in interleukin (IL) 6‐induced B cell differentiation was assessed. Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c‐fos sense mRNA expression. The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c‐fos significantly inhibited IL 6‐induced IgM production by SKW 6.4 cells (p < 0.001), whereas control oligonucleotides had no inhibitory effect. These results indicate that activation of c‐fos is involved in IL 6‐induced differentiation of SKW 6.4 cells into IgM‐secreting cells.

UR - https://www.scopus.com/pages/publications/0026527169

U2 - 10.1002/eji.1830220248

DO - 10.1002/eji.1830220248

M3 - Article

C2 - 1537389

AN - SCOPUS:0026527169

SN - 0014-2980

VL - 22

SP - 607

EP - 610

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 2

ER -

Interleukin 6‐induced differentiation of a human B cell line into IgM‐secreting plasma cells is mediated by c‐fos

Abstract

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