Interleukin-17 and type 17 helper T cells

Pierre Miossec; Thomas Korn; Vijay K. Kuchroo

doi:10.1056/NEJMra0707449

Interleukin-17 and type 17 helper T cells

Pierre Miossec, Thomas Korn, Vijay K. Kuchroo

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Research output: Contribution to journal › Review article › peer-review

1218 Scopus citations

Abstract

Type 17 helper T cells (Th17) - a third class of T cells - and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.

Original language	English
Pages (from-to)	888
Number of pages	1
Journal	New England Journal of Medicine
Volume	361
Issue number	9
DOIs	https://doi.org/10.1056/NEJMra0707449
State	Published - 27 Aug 2009

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10.1056/NEJMra0707449

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title = "Interleukin-17 and type 17 helper T cells",

abstract = "Type 17 helper T cells (Th17) - a third class of T cells - and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.",

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AU - Miossec, Pierre

AU - Korn, Thomas

AU - Kuchroo, Vijay K.

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N2 - Type 17 helper T cells (Th17) - a third class of T cells - and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.

AB - Type 17 helper T cells (Th17) - a third class of T cells - and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.

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VL - 361

SP - 888

JO - New England Journal of Medicine

JF - New England Journal of Medicine

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ER -

Interleukin-17 and type 17 helper T cells

Abstract

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