INTENSIVE IMMUNOSUPPRESSION IN THE TREATMENT OF MULTIPLE SCLEROSIS

J. Ring; G. Lob; H. Angstwurm; B. Brass; H. Backmund; J. Seifert; K. Coulin; E. Frick; J. Mertin; W. Brendel

doi:10.1016/S0140-6736(74)90866-6

INTENSIVE IMMUNOSUPPRESSION IN THE TREATMENT OF MULTIPLE SCLEROSIS

J. Ring, G. Lob, H. Angstwurm, B. Brass, H. Backmund, J. Seifert, K. Coulin, E. Frick, J. Mertin, W. Brendel

Ludwig-Maximilians-Universität München

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Twenty patients with the chronic progressive (seven) or intermittent relapsing (thirteen) form of multiple sclerosis have been treated with intravenous anti-lymphocyte globulin (seven), thoracic-duct drainage (five), or a combination of both (nine), together with azathioprine and steroids, which had been given before treatment without success. In thirteen patients induction of immunological unresponsiveness against horse IgG was attempted and this was successful in eight. Clinical effect was evaluated using the Bronx and Fog scales with follow-up for 1-5 years. 11 patients showed significant clinical improvement. Lymphopenia seemed to be some index of the therapeutic effect: in patients in whom gross lymphopenia was never achieved during treatment, clinical changes were only slight. By the induction of immunological unresponsiveness against horse IgG the clinical efficacy of A.L.G. was significantly improved.

Original language	English
Pages (from-to)	1093-1096
Number of pages	4
Journal	The Lancet
Volume	304
Issue number	7889
DOIs	https://doi.org/10.1016/S0140-6736(74)90866-6
State	Published - 9 Nov 1974
Externally published	Yes

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title = "INTENSIVE IMMUNOSUPPRESSION IN THE TREATMENT OF MULTIPLE SCLEROSIS",

abstract = "Twenty patients with the chronic progressive (seven) or intermittent relapsing (thirteen) form of multiple sclerosis have been treated with intravenous anti-lymphocyte globulin (seven), thoracic-duct drainage (five), or a combination of both (nine), together with azathioprine and steroids, which had been given before treatment without success. In thirteen patients induction of immunological unresponsiveness against horse IgG was attempted and this was successful in eight. Clinical effect was evaluated using the Bronx and Fog scales with follow-up for 1-5 years. 11 patients showed significant clinical improvement. Lymphopenia seemed to be some index of the therapeutic effect: in patients in whom gross lymphopenia was never achieved during treatment, clinical changes were only slight. By the induction of immunological unresponsiveness against horse IgG the clinical efficacy of A.L.G. was significantly improved.",

author = "J. Ring and G. Lob and H. Angstwurm and B. Brass and H. Backmund and J. Seifert and K. Coulin and E. Frick and J. Mertin and W. Brendel",

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T1 - INTENSIVE IMMUNOSUPPRESSION IN THE TREATMENT OF MULTIPLE SCLEROSIS

AU - Ring, J.

AU - Lob, G.

AU - Angstwurm, H.

AU - Brass, B.

AU - Backmund, H.

AU - Seifert, J.

AU - Coulin, K.

AU - Frick, E.

AU - Mertin, J.

AU - Brendel, W.

PY - 1974/11/9

Y1 - 1974/11/9

N2 - Twenty patients with the chronic progressive (seven) or intermittent relapsing (thirteen) form of multiple sclerosis have been treated with intravenous anti-lymphocyte globulin (seven), thoracic-duct drainage (five), or a combination of both (nine), together with azathioprine and steroids, which had been given before treatment without success. In thirteen patients induction of immunological unresponsiveness against horse IgG was attempted and this was successful in eight. Clinical effect was evaluated using the Bronx and Fog scales with follow-up for 1-5 years. 11 patients showed significant clinical improvement. Lymphopenia seemed to be some index of the therapeutic effect: in patients in whom gross lymphopenia was never achieved during treatment, clinical changes were only slight. By the induction of immunological unresponsiveness against horse IgG the clinical efficacy of A.L.G. was significantly improved.

AB - Twenty patients with the chronic progressive (seven) or intermittent relapsing (thirteen) form of multiple sclerosis have been treated with intravenous anti-lymphocyte globulin (seven), thoracic-duct drainage (five), or a combination of both (nine), together with azathioprine and steroids, which had been given before treatment without success. In thirteen patients induction of immunological unresponsiveness against horse IgG was attempted and this was successful in eight. Clinical effect was evaluated using the Bronx and Fog scales with follow-up for 1-5 years. 11 patients showed significant clinical improvement. Lymphopenia seemed to be some index of the therapeutic effect: in patients in whom gross lymphopenia was never achieved during treatment, clinical changes were only slight. By the induction of immunological unresponsiveness against horse IgG the clinical efficacy of A.L.G. was significantly improved.

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ER -

INTENSIVE IMMUNOSUPPRESSION IN THE TREATMENT OF MULTIPLE SCLEROSIS

Abstract

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