Insulitis des Typ-1-Diabetes

P. In’t Veld; G. Klöppel

doi:10.1007/s00292-016-0166-8

Insulitis des Typ-1-Diabetes

Translated title of the contribution: Insulitis in type 1 diabetes

P. In’t Veld, G. Klöppel

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Vrije Universiteit Brussel

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Insulitis is considered to be the key morphological lesion of type 1 diabetes mellitus (T1DM) for which the diagnostic criteria were recently defined. From the immunophenotype of the lymphocytic infiltration, its frequency and extent during the course of T1DM and the presence of autoantibodies against beta cell proteins, it has been deduced that T1DM is a chronic autoimmune disease leading to gradual destruction of the insulin-producing cells of the islets of Langerhans in the pancreas, profound insulin deficiency and chronic hyperglycemia. This review article presents the morphological findings that support this hypothesis and addresses questions that need to be answered in order to further clarify the pathogenesis and to develop specific treatment options.

Translated title of the contribution	Insulitis in type 1 diabetes
Original language	German
Pages (from-to)	245-252
Number of pages	8
Journal	Pathologe
Volume	37
Issue number	3
DOIs	https://doi.org/10.1007/s00292-016-0166-8
State	Published - 1 May 2016

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title = "Insulitis des Typ-1-Diabetes",

abstract = "Insulitis is considered to be the key morphological lesion of type 1 diabetes mellitus (T1DM) for which the diagnostic criteria were recently defined. From the immunophenotype of the lymphocytic infiltration, its frequency and extent during the course of T1DM and the presence of autoantibodies against beta cell proteins, it has been deduced that T1DM is a chronic autoimmune disease leading to gradual destruction of the insulin-producing cells of the islets of Langerhans in the pancreas, profound insulin deficiency and chronic hyperglycemia. This review article presents the morphological findings that support this hypothesis and addresses questions that need to be answered in order to further clarify the pathogenesis and to develop specific treatment options.",

keywords = "Diabetes mellitus, type 1, Morphological findings, Pancreas, Pathogenesis, Therapy",

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AU - Klöppel, G.

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N2 - Insulitis is considered to be the key morphological lesion of type 1 diabetes mellitus (T1DM) for which the diagnostic criteria were recently defined. From the immunophenotype of the lymphocytic infiltration, its frequency and extent during the course of T1DM and the presence of autoantibodies against beta cell proteins, it has been deduced that T1DM is a chronic autoimmune disease leading to gradual destruction of the insulin-producing cells of the islets of Langerhans in the pancreas, profound insulin deficiency and chronic hyperglycemia. This review article presents the morphological findings that support this hypothesis and addresses questions that need to be answered in order to further clarify the pathogenesis and to develop specific treatment options.

AB - Insulitis is considered to be the key morphological lesion of type 1 diabetes mellitus (T1DM) for which the diagnostic criteria were recently defined. From the immunophenotype of the lymphocytic infiltration, its frequency and extent during the course of T1DM and the presence of autoantibodies against beta cell proteins, it has been deduced that T1DM is a chronic autoimmune disease leading to gradual destruction of the insulin-producing cells of the islets of Langerhans in the pancreas, profound insulin deficiency and chronic hyperglycemia. This review article presents the morphological findings that support this hypothesis and addresses questions that need to be answered in order to further clarify the pathogenesis and to develop specific treatment options.

KW - Diabetes mellitus, type 1

KW - Morphological findings

KW - Pancreas

KW - Pathogenesis

KW - Therapy

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Insulitis des Typ-1-Diabetes

Abstract

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