Insights from multi-omics integration in complex disease primary tissues

Peter Kreitmaier, Georgia Katsoula, Eleftheria Zeggini

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Genome-wide association studies (GWAS) have provided insights into the genetic basis of complex diseases. In the next step, integrative multi-omics approaches can characterize molecular profiles in relevant primary tissues to reveal the mechanisms that underlie disease development. Here, we highlight recent progress in four examples of complex diseases generated by integrative studies: type 2 diabetes (T2D), osteoarthritis, Alzheimer's disease (AD), and systemic lupus erythematosus (SLE). High-resolution methodologies such as single-cell and spatial omics techniques will become even more important in the future. Furthermore, we emphasize the urgent need to include as yet understudied cell types and increase the diversity of studied populations.

Original languageEnglish
Pages (from-to)46-58
Number of pages13
JournalTrends in Genetics
Volume39
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • Alzheimer's disease
  • multi-omics
  • osteoarthritis
  • primary tissue
  • systemic lupus erythematosus
  • type 2 diabetes

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