Abstract
Several studies have suggested an association between type 1 and type 2 diabetes. In order to determine whether descendants of patients with type 2 diabetes have an increased prevalence of type 1 diabetes-associated autoimmune markers, islet autoantibodies were determined in sera of 142 offspring and 190 grandchildren from patients with type 2 diabetes and of 405 offspring from mothers with gestational diabetes. The antibody prevalence was 0% (95% CI 0%) in offspring and 0.5% (95% CI 0-3%) in the grandchildren of patients with type 2 diabetes and 1.2% (95% CI 0-3%) in the offspring of mothers with gestational diabetes. Of the 6 antibody positive relatives 4 had one single antibody specificity and two of these had GADA. One child had ICA together with GADA and one offspring of a mother with gestational diabetes had all four antibody reactivities (ICA, IAA, GADA, IA-2A). He developed clinical type 1 diabetes three years later. This child was the only one of the antibody positive relatives with a high risk HLA DR 3/4 (DQB1*0201/0302) genotype. We conclude that type 2 diabetes or gestational diabetes is not associated with an increased risk for islet autoimmunity in descendants. Therefore we see no need for preferential screening of islet autoantibodies in relatives of patients with type 2 or gestational diabetes.
| Translated title of the contribution | Frequency of islet autoantibodies in relatives of patients with type 2 or gestational diabetes |
|---|---|
| Original language | German |
| Pages (from-to) | 3-7 |
| Number of pages | 5 |
| Journal | Diabetes und Stoffwechsel |
| Volume | 9 |
| Issue number | 1 |
| State | Published - 20 Jan 2000 |
| Externally published | Yes |
