TY - JOUR
T1 - Innovations in phenotyping of mouse models in the German Mouse Clinic
AU - Fuchs, Helmut
AU - Gailus-Durner, Valérie
AU - Neschen, Susanne
AU - Adler, Thure
AU - Afonso, Luciana Caminha
AU - Aguilar-Pimentel, Juan Antonio
AU - Becker, Lore
AU - Bohla, Alexander
AU - Calzada-Wack, Julia
AU - Cohrs, Christian
AU - Dewert, Anna
AU - Fridrich, Barbara
AU - Garrett, Lillian
AU - Glasl, Lisa
AU - Götz, Alexander
AU - Hans, Wolfgang
AU - Hölter, Sabine M.
AU - Horsch, Marion
AU - Hurt, Anja
AU - Janas, Eva
AU - Janik, Dirk
AU - Kahle, Melanie
AU - Kistler, Martin
AU - Klein-Rodewald, Tanja
AU - Lengger, Christoph
AU - Ludwig, Tonia
AU - Maier, Holger
AU - Marschall, Susan
AU - Micklich, Kateryna
AU - Möller, Gabriele
AU - Naton, Beatrix
AU - Prehn, Cornelia
AU - Puk, Oliver
AU - Rácz, Ildikó
AU - Räß, Michael
AU - Rathkolb, Birgit
AU - Rozman, Jan
AU - Scheerer, Markus
AU - Schiller, Evelyn
AU - Schrewe, Anja
AU - Steinkamp, Ralph
AU - Stöger, Claudia
AU - Sun, Minxuan
AU - Szymczak, Wilfried
AU - Treise, Irina
AU - Vargas Panesso, Ingrid Liliana
AU - Vernaleken, Alexandra M.
AU - Willershäuser, Monja
AU - Wolff-Muscate, Annemarie
AU - Zeh, Ramona
AU - Adamski, Jerzy
AU - Beckers, Johannes
AU - Bekeredjian, Raffi
AU - Busch, Dirk H.
AU - Eickelberg, Oliver
AU - Favor, Jack
AU - Graw, Jochen
AU - Höfler, Heinz
AU - Höschen, Christoph
AU - Katus, Hugo
AU - Klingenspor, Martin
AU - Klopstock, Thomas
AU - Neff, Frauke
AU - Ollert, Markus
AU - Schulz, Holger
AU - Stöger, Tobias
AU - Wolf, Eckhard
AU - Wurst, Wolfgang
AU - Yildirim, Ali Önder
AU - Zimmer, Andreas
AU - Hrabě De Angelis, Martin
N1 - Funding Information:
We thank Reinhard Seeliger, Anke Bettenbrock, Nicole Boche, Jan Einicke, Daniel Feeser, Ralf Fischer, Birgit Frankenberger, Sandra Geißler, Brigitte Herrmann, Christine Hollauer, Elfi Holupirek, Maria Kugler, Jacqueline Müller, Anna Nießer, Simon Orth, Elenore Samson, Florian Schleicher, Waldemar Schneider, Nancy Schulze, Ann-Elisabeth Schwarz, Nadine Senger, Yvonne Sonntag, Bettina Sperling, Waldtraud Stettinger, Alida Theil, Lucie Thurmann, Susanne Wittich, Anja Wohlbier, and Claudia Zeller, as well as the GMC animal caretaker team Manuela Huber, Boris Schön, Heidi Marr, Annica Miedl, Tina Reichelt, Michael Gerstlauer, Renate Huber, and Horst Wenig for expert technical help. This work was funded by a German Federal Ministry of Education and Research grant to the German Center for Diabetes Research (DZD e.V.) and to the GMC (NGFN-Plus grant Nos. 01GS0850, 01GS0851, 01GS0852, 01GS0853, 01GS0854, GS0868, 01GS0869; Infrafrontier grant 01KX1012), by the Initiative and Networking Fund of the Helmholtz Association in the framework of the Helmholtz Alliance for Mental Research in an Aging Society (HA-215), and by an EU grant (EUMODIC, LSHG-2006-037188, Infrafrontier Contract No. 211404, German Mouse Clinic).
PY - 2012/10
Y1 - 2012/10
N2 - Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ("bottom-up projects") and as a partner and driver in international large-scale biology projects ("topdown projects"). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).
AB - Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ("bottom-up projects") and as a partner and driver in international large-scale biology projects ("topdown projects"). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).
UR - http://www.scopus.com/inward/record.url?scp=84867329301&partnerID=8YFLogxK
U2 - 10.1007/s00335-012-9415-1
DO - 10.1007/s00335-012-9415-1
M3 - Article
C2 - 22926221
AN - SCOPUS:84867329301
SN - 0938-8990
VL - 23
SP - 611
EP - 622
JO - Mammalian Genome
JF - Mammalian Genome
IS - 9-10
ER -