Innate Recognition of Viruses

Andreas Pichlmair; Caetano Reis e Sousa

doi:10.1016/j.immuni.2007.08.012

Innate Recognition of Viruses

Andreas Pichlmair, Caetano Reis e Sousa

Cancer Research UK

Research output: Contribution to journal › Review article › peer-review

591 Scopus citations

Abstract

Virus infection elicits potent responses in all cells intended to contain virus spread before intervention by the adaptive immune system. Central to this process is the virus-elicited production of type I interferons (IFNs) and other cytokines. The sensors involved in coupling recognition of viruses to the induction of the type I IFN genes have only recently been uncovered and include endosomal and cytosolic receptors for RNA and DNA. Here, we review their properties and discuss how their ability to recognize the unusual presence of atypical nucleic acids in particular subcellular compartments is used by the body to detect virus presence.

Original language	English
Pages (from-to)	370-383
Number of pages	14
Journal	Immunity
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2007.08.012
State	Published - 21 Sep 2007
Externally published	Yes

Keywords

MOLIMMUNO

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2007.08.012

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title = "Innate Recognition of Viruses",

abstract = "Virus infection elicits potent responses in all cells intended to contain virus spread before intervention by the adaptive immune system. Central to this process is the virus-elicited production of type I interferons (IFNs) and other cytokines. The sensors involved in coupling recognition of viruses to the induction of the type I IFN genes have only recently been uncovered and include endosomal and cytosolic receptors for RNA and DNA. Here, we review their properties and discuss how their ability to recognize the unusual presence of atypical nucleic acids in particular subcellular compartments is used by the body to detect virus presence.",

keywords = "MOLIMMUNO",

author = "Andreas Pichlmair and {Reis e Sousa}, Caetano",

note = "Funding Information: We are grateful to C. Johansson, O. Schulz, and C.-P. Tan for critical review of the manuscript. Work in the authors' laboratory is funded by Cancer Research UK.",

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doi = "10.1016/j.immuni.2007.08.012",

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AU - Pichlmair, Andreas

AU - Reis e Sousa, Caetano

N1 - Funding Information: We are grateful to C. Johansson, O. Schulz, and C.-P. Tan for critical review of the manuscript. Work in the authors' laboratory is funded by Cancer Research UK.

PY - 2007/9/21

Y1 - 2007/9/21

N2 - Virus infection elicits potent responses in all cells intended to contain virus spread before intervention by the adaptive immune system. Central to this process is the virus-elicited production of type I interferons (IFNs) and other cytokines. The sensors involved in coupling recognition of viruses to the induction of the type I IFN genes have only recently been uncovered and include endosomal and cytosolic receptors for RNA and DNA. Here, we review their properties and discuss how their ability to recognize the unusual presence of atypical nucleic acids in particular subcellular compartments is used by the body to detect virus presence.

AB - Virus infection elicits potent responses in all cells intended to contain virus spread before intervention by the adaptive immune system. Central to this process is the virus-elicited production of type I interferons (IFNs) and other cytokines. The sensors involved in coupling recognition of viruses to the induction of the type I IFN genes have only recently been uncovered and include endosomal and cytosolic receptors for RNA and DNA. Here, we review their properties and discuss how their ability to recognize the unusual presence of atypical nucleic acids in particular subcellular compartments is used by the body to detect virus presence.

KW - MOLIMMUNO

UR - http://www.scopus.com/inward/record.url?scp=34548694962&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2007.08.012

DO - 10.1016/j.immuni.2007.08.012

M3 - Review article

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AN - SCOPUS:34548694962

SN - 1074-7613

VL - 27

SP - 370

EP - 383

JO - Immunity

JF - Immunity

IS - 3

ER -

Innate Recognition of Viruses

Abstract

Keywords

UN SDGs

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