Abstract
The methanol extracts of Hibiscus sabdariffa (p < 0.01) showed a significant dose dependent relaxant effect (IC50 = 350 μM) on rat ileal strip comparable to the effect shown by nifedipin and papaverine as reference compounds. Similarly, the extract when administered intraperitoneally significantly (p < 0.05-0.01) reduced the intestinal transit (13%-35%) in rats (IC50 = 250 μM). The extracts (40% ± 04%) and nifedipin (51% ± 05%) also potentiated the diarrhoea inducing effect of castor oil (IC50 = 350 μM). It is postulated that these effects are possibly generated by constituents such as quercetin and eugenol via a Ca2+ channel modulated mode of action.
Original language | English |
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Pages (from-to) | 283-285 |
Number of pages | 3 |
Journal | Phytotherapy Research |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |
Keywords
- Hibiscus sabdariffa
- Malvaceae
- Relaxant effect