Inhibition of dihydrofolate reductase by mofebutazon

Elke Strehl; Ingrid Schneider; Erich F. Elstner

doi:10.1515/znc-1993-9-1022

Inhibition of dihydrofolate reductase by mofebutazon

Elke Strehl
, Ingrid Schneider
, Erich F. Elstner

Life Sciences

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

Abstract

Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. A n apparent k₁ for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2mM was calculated.

Original language	English
Pages (from-to)	815-817
Number of pages	3
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	48
Issue number	9-10
DOIs	https://doi.org/10.1515/znc-1993-9-1022
State	Published - 1 Oct 1993

Keywords

Dihydrofolate Reductase
Mofebutazon
Non-Steroidal Antiinflammatory Drugs (NSAIDs)

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10.1515/znc-1993-9-1022

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abstract = "Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. A n apparent k1 for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2mM was calculated.",

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AU - Schneider, Ingrid

AU - Elstner, Erich F.

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N2 - Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. A n apparent k1 for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2mM was calculated.

AB - Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. A n apparent k1 for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2mM was calculated.

KW - Dihydrofolate Reductase

KW - Mofebutazon

KW - Non-Steroidal Antiinflammatory Drugs (NSAIDs)

UR - https://www.scopus.com/pages/publications/0027655616

U2 - 10.1515/znc-1993-9-1022

DO - 10.1515/znc-1993-9-1022

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SN - 0939-5075

VL - 48

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EP - 817

JO - Zeitschrift fur Naturforschung - Section C Journal of Biosciences

JF - Zeitschrift fur Naturforschung - Section C Journal of Biosciences

IS - 9-10

ER -

Inhibition of dihydrofolate reductase by mofebutazon

Abstract

Keywords

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