Inhibition of dihydrofolate reductase activity by alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea

E. Strehl, W. Schneider, E. F. Elstner

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15 Scopus citations

Abstract

Aqueous-ethanolic extracts of Fraxinus excelsior, Populus tremula and Solidago virgaurea in a combination of 1:3:1 (v/v/v) are the components of the plant drug Phytodolor® N (abbreviated as PD), which exhibits antipyretic, analgesic and antirheumatic activity. Similar to a broad variety of synthetic non-steroidal anti-inflammatories the mentioned plant extracts inhibit dihydrofolate reductase. The following concentrations as percentage in the test volumes represent the individual I50-values: F. excelsior = 0.26% (v/v); P. tremula = 0.46% (v/v) and S. virgaurea = 0.6% (v/v). The combined extracts in PD exhibit an I50 at 0.3% (v/v). Testig the activity of the water-soluble compounds of corresponding dry extracts, the activity of F. excelsior with an apparent I50-value of 0.008% (w/v) by far dominates the inhibitory overall effect of the combination (I50 = 0.014%, w/v).

Original languageEnglish
Pages (from-to)172-173
Number of pages2
JournalArzneimittel-Forschung/Drug Research
Volume45
Issue number2
StatePublished - 1995

Keywords

  • Fraxinus excelsior
  • Phytodolor® N
  • Populus tremula
  • Solidago virgaurea
  • anti-inflammatories
  • dihydrofolate reductase

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