Inhalation pharmacokinetics based on gas uptake studies - V. Comparative pharmacokinetics of ethylene and 1,3-butadiene in rats

H. M. Bolt, J. G. Filser, F. Störmer

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65 Scopus citations

Abstract

The pharmacokinetics of ethylene and 1,3-butadiene were studied in male Sprague-Dawley rats by use of a closed inhalation chamber system. Both compounds showed saturable metabolism when untreated rats were used. "Linear" pharmacokinetics applied at exposure concentrations below 800 ppm ethylene and below 1,000 ppm 1,3-butadiene. A constant elimination rate, indicative of metabolic saturation, occurred at concentrations higher than 1,000 ppm ethylene or 1,500 ppm 1,3-butadiene. Pretreatment with aroclor 1254 (polychlorinated biphenyls) increased Vmax for both compounds. For 1,3-butadiene, no saturation of metabolic capacity was observed with exposure concentrations up to 12,000 ppm when the rats were pretreated with aroclor 1254. A comparison with previous studies on ethane and n-pentane suggested that introduction of a double bond into a saturated aliphatic hydrocarbon increased the rate of metabolism under conditions in vivo.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalArchives of Toxicology
Volume55
Issue number4
DOIs
StatePublished - Oct 1984
Externally publishedYes

Keywords

  • 1,3-Butadiene
  • Ethylene
  • Inhalation
  • Pharmacokinetics

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