Influence of 11C-choline PET/CT on the treatment planning for salvage radiation therapy in patients with biochemical recurrence of prostate cancer

Michael Souvatzoglou, Bernd J. Krause, Anja Pürschel, Reinhard Thamm, Tibor Schuster, Andreas K. Buck, Frank Zimmermann, Michael Molls, Markus Schwaiger, Hans Geinitz

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Background and purpose: The present study evaluates the incidence of 11C-choline PET/CT positive findings in patients with recurrent prostate cancer referred for salvage radiotherapy (SRT) and the influence on the definition of the planning target volume (PTV). Material and methods: Thirty-seven patients treated with radical prostatectomy and referred to SRT to the prostatic fossa because of biochemical relapse, were analysed retrospectively. All patients underwent 11C-choline PET/CT before radiotherapy. The influence of PET/CT on the extent of the PTV was analysed. The median total follow up after SRT was 51.2 months. Results: 11/37 (30%) patients had a positive finding in the 11C-choline PET/CT, 5 (13%) outside of the prostatic fossa (iliac lymph nodes), implicating an extension of the PTV. Patients with positive 11C-choline PET/CT had a significant higher PSA value than patients with no pathologic uptake (p = 0.03). Overall, at the end of follow up 56% of the patients had a PSA ≤ 0.2 ng/ml and 44% had a biochemical relapse of prostate cancer. Conclusions: 11C-choline PET/CT detects abnormalities outside of the prostatic fossa in 13% of patients referred for SRT because of biochemical relapse after radical prostatectomy, affecting the extent of the PTV. Prospective studies need to be implemented to evaluate the benefit of SRT with a PTV based on 11C-choline PET/CT.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalRadiotherapy and Oncology
Volume99
Issue number2
DOIs
StatePublished - May 2011

Keywords

  • C-choline PET/CT
  • Prostate cancer recurrence
  • Salvage radiotherapy

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