TY - JOUR
T1 - Influence of 11C-choline PET/CT on the treatment planning for salvage radiation therapy in patients with biochemical recurrence of prostate cancer
AU - Souvatzoglou, Michael
AU - Krause, Bernd J.
AU - Pürschel, Anja
AU - Thamm, Reinhard
AU - Schuster, Tibor
AU - Buck, Andreas K.
AU - Zimmermann, Frank
AU - Molls, Michael
AU - Schwaiger, Markus
AU - Geinitz, Hans
PY - 2011/5
Y1 - 2011/5
N2 - Background and purpose: The present study evaluates the incidence of 11C-choline PET/CT positive findings in patients with recurrent prostate cancer referred for salvage radiotherapy (SRT) and the influence on the definition of the planning target volume (PTV). Material and methods: Thirty-seven patients treated with radical prostatectomy and referred to SRT to the prostatic fossa because of biochemical relapse, were analysed retrospectively. All patients underwent 11C-choline PET/CT before radiotherapy. The influence of PET/CT on the extent of the PTV was analysed. The median total follow up after SRT was 51.2 months. Results: 11/37 (30%) patients had a positive finding in the 11C-choline PET/CT, 5 (13%) outside of the prostatic fossa (iliac lymph nodes), implicating an extension of the PTV. Patients with positive 11C-choline PET/CT had a significant higher PSA value than patients with no pathologic uptake (p = 0.03). Overall, at the end of follow up 56% of the patients had a PSA ≤ 0.2 ng/ml and 44% had a biochemical relapse of prostate cancer. Conclusions: 11C-choline PET/CT detects abnormalities outside of the prostatic fossa in 13% of patients referred for SRT because of biochemical relapse after radical prostatectomy, affecting the extent of the PTV. Prospective studies need to be implemented to evaluate the benefit of SRT with a PTV based on 11C-choline PET/CT.
AB - Background and purpose: The present study evaluates the incidence of 11C-choline PET/CT positive findings in patients with recurrent prostate cancer referred for salvage radiotherapy (SRT) and the influence on the definition of the planning target volume (PTV). Material and methods: Thirty-seven patients treated with radical prostatectomy and referred to SRT to the prostatic fossa because of biochemical relapse, were analysed retrospectively. All patients underwent 11C-choline PET/CT before radiotherapy. The influence of PET/CT on the extent of the PTV was analysed. The median total follow up after SRT was 51.2 months. Results: 11/37 (30%) patients had a positive finding in the 11C-choline PET/CT, 5 (13%) outside of the prostatic fossa (iliac lymph nodes), implicating an extension of the PTV. Patients with positive 11C-choline PET/CT had a significant higher PSA value than patients with no pathologic uptake (p = 0.03). Overall, at the end of follow up 56% of the patients had a PSA ≤ 0.2 ng/ml and 44% had a biochemical relapse of prostate cancer. Conclusions: 11C-choline PET/CT detects abnormalities outside of the prostatic fossa in 13% of patients referred for SRT because of biochemical relapse after radical prostatectomy, affecting the extent of the PTV. Prospective studies need to be implemented to evaluate the benefit of SRT with a PTV based on 11C-choline PET/CT.
KW - C-choline PET/CT
KW - Prostate cancer recurrence
KW - Salvage radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=79958152808&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2011.05.005
DO - 10.1016/j.radonc.2011.05.005
M3 - Article
C2 - 21620494
AN - SCOPUS:79958152808
SN - 0167-8140
VL - 99
SP - 193
EP - 200
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 2
ER -
