Influence of Polymorphism within the Heme Oxygenase-I Promoter on Overall Survival and Transplantation-Related Mortality after Allogeneic Stem Cell Transplantation

Armin Gerbitz, Patrick Hillemanns, Christoph Schmid, Andrea Wilke, Rajshri Jayaraman, Hans Jochem Kolb, Gunther Eissner, Ernst Holler

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Aside from major and minor histocompatibility antigens, genetic polymorphisms of various donor and host genes have been found to be risk factors for graft-versus-host disease and transplantation-related mortality (TRM). The heme oxygenase I (HO-I) protein has been implicated in regulating inflammatory response and has been described as a "protective gene" in solid organ transplantation. In humans, the promoter region displays length polymorphism due to a variable number of GT repeats. Individuals exhibiting 29 or fewer GT repeats express higher levels of HO-I on cellular stress compared with individuals with 30 or more GT repeats. We retrospectively analyzed length polymorphisms of 92 donor-host pairs undergoing allogeneic stem cell transplantation. Our findings demonstrate that mainly donor polymorphism leading to high expression of HO-1 (<30 GT repeats) on stress signals is associated with reduced overall survival, and that TRM is significantly increased in this group. This reduction in survival was most prominent when unrelated donors were used. Polymorphisms of the recipient HO-1 genes did not influence posttransplantation outcomes. We conclude that HO-1 polymorphism represents a new genetic risk factor for TRM and overall survival.

Original languageEnglish
Pages (from-to)1180-1189
Number of pages10
JournalBiology of Blood and Marrow Transplantation
Volume14
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

Keywords

  • Graft-versus-host disease
  • Heme oxygenase
  • Polymorphism
  • Risk factor
  • Stem cell transplantation

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