Influence of animal heating on PET imaging quantification and kinetics: Biodistribution of 18F-tetrafluoroborate and 18F-FDG in mice

Christian Goetz, Matthias Podein, Friederike Braun, Wolfgang A. Weber, Philippe Choquet, André Constantinesco, Michael Mix

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Different environmental conditions under anesthesia may lead to unstable homeostatic conditions in rodents and therefore may alter kinetics. In this study, the impact of different heating conditions on PET imaging quantification was evaluated. Methods: Two groups of 6 adult female BALB/c nude mice with subcutaneously implanted tumors underwent microPET imaging after injection of 18F-labeled tetrafluoroborate or 18F-FDG. Dynamic scans were acquired under optimal and suboptimal heating conditions. Time-activity curves were analyzed to calculate uptake and washout time constants. Results: With 18F-labeled tetrafluoroborate, optimal animal heating led to a stable heart rate during acquisition (515 6 35 [mean 6 SD] beats/min), whereas suboptimal heating led to a lower heart rate and a higher SD (470 6 84 beats/min). Both uptake and washout time constants were faster (P , 0.01) in animals maintained with optimal heating. Conclusion: Although the difference in heart rates was slight, optimal heating yielded significantly faster uptake and washout kinetics than suboptimal heating in all organs for both tracers.

Original languageEnglish
Pages (from-to)1162-1166
Number of pages5
JournalJournal of Nuclear Medicine
Volume58
Issue number7
DOIs
StatePublished - 1 Jul 2017
Externally publishedYes

Keywords

  • Homeostasis
  • PET kinetics
  • Tracer biodistribution
  • Xenografts

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