Inflammation-related risk loci in genome-wide association studies of coronary artery disease

Carina Mauersberger, Heribert Schunkert, Hendrik B. Sager

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Although the importance of inflammation in atherosclerosis is now well established, the exact molecular processes linking inflammation to the development and course of the disease are not sufficiently understood. In this context, modern genetics—as applied by genome-wide association studies (GWAS)—can serve as a comprehensive and unbiased tool for the screening of potentially involved pathways. Indeed, a considerable proportion of loci discovered by GWAS is assumed to affect inflammatory processes. Despite many well-replicated association findings, however, translating genomic hits to specific molecular mechanisms remains challenging. This review provides an overview of the currently most relevant inflammation-related GWAS findings in coronary artery disease and explores their potential clinical perspectives.

Original languageEnglish
Article number440
Pages (from-to)1-15
Number of pages15
JournalCells
Volume10
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Genetics
  • Genome-wide association studies
  • Inflammation

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