Inflammation, immunity, and vaccines for Helicobacter pylori infection

Dominique Velin; Kathrin Straubinger; Markus Gerhard

doi:10.1111/hel.12336

Inflammation, immunity, and vaccines for Helicobacter pylori infection

Dominique Velin, Kathrin Straubinger, Markus Gerhard

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H. pylori/host interactions. In addition, the latest preclinical developments of H. pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng et al., who provided evidence that oral vaccination significantly reduces the acquisition of natural H. pylori infection in children.

Original language	English
Pages (from-to)	26-29
Number of pages	4
Journal	Helicobacter
Volume	21
DOIs	https://doi.org/10.1111/hel.12336
State	Published - 1 Sep 2016
Externally published	Yes

Keywords

H. pylori
innate and adaptive immunity
vaccine development

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/hel.12336

Cite this

@article{4d21ed1a550143f2ad2822896f0a7da0,

title = "Inflammation, immunity, and vaccines for Helicobacter pylori infection",

abstract = "The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H. pylori/host interactions. In addition, the latest preclinical developments of H. pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng et al., who provided evidence that oral vaccination significantly reduces the acquisition of natural H. pylori infection in children.",

keywords = "H. pylori, innate and adaptive immunity, vaccine development",

author = "Dominique Velin and Kathrin Straubinger and Markus Gerhard",

note = "Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons Ltd",

year = "2016",

month = sep,

day = "1",

doi = "10.1111/hel.12336",

language = "English",

volume = "21",

pages = "26--29",

journal = "Helicobacter",

issn = "1083-4389",

publisher = "Wiley-Blackwell Publishing Ltd",

}

TY - JOUR

T1 - Inflammation, immunity, and vaccines for Helicobacter pylori infection

AU - Velin, Dominique

AU - Straubinger, Kathrin

AU - Gerhard, Markus

PY - 2016/9/1

Y1 - 2016/9/1

N2 - The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H. pylori/host interactions. In addition, the latest preclinical developments of H. pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng et al., who provided evidence that oral vaccination significantly reduces the acquisition of natural H. pylori infection in children.

AB - The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H. pylori/host interactions. In addition, the latest preclinical developments of H. pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng et al., who provided evidence that oral vaccination significantly reduces the acquisition of natural H. pylori infection in children.

KW - H. pylori

KW - innate and adaptive immunity

KW - vaccine development

UR - http://www.scopus.com/inward/record.url?scp=84982187282&partnerID=8YFLogxK

U2 - 10.1111/hel.12336

DO - 10.1111/hel.12336

M3 - Review article

C2 - 27531535

AN - SCOPUS:84982187282

SN - 1083-4389

VL - 21

SP - 26

EP - 29

JO - Helicobacter

JF - Helicobacter

ER -

Inflammation, immunity, and vaccines for Helicobacter pylori infection

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this