Inflammasome: Putting the pieces together

Research output: Contribution to journalShort surveypeer-review

29 Scopus citations

Abstract

Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.

Original languageEnglish
Pages (from-to)1127-1129
Number of pages3
JournalCell
Volume156
Issue number6
DOIs
StatePublished - 13 Mar 2014
Externally publishedYes

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