Infektionen und immuntherapie: Adoptiver transfer antigenspezifischer T-zellen bei infektionen nach allogener stammzelltransplantation

Translated title of the contribution: Infections after allogeneic stem cell transplantation. Treatment by adoptive transfer of antigen-specific T cells

T. Feuchtinger, U. Behrends, T. Lehrnbecher

Research output: Contribution to journalReview articlepeer-review

Abstract

Allogeneic stem cell transplantation (SCT) can expose patients to a transient but marked immunosuppression, during which viral and fungal infections are an important cause of morbidity and mortality. Control of these infections ultimately depends on restoring adequate T-cell immunity. Most viral infections after SCT are caused by the endogenous reactivation of persistent pathogens such as adenovirus (ADV), cytomegalovirus (CMV), and Epstein-Barr-virus (EBV), whereas invasive infections due to Aspergillus spp. are mostly exogenous. Cellular immunotherapy is an attractive approach to enable immune protection of the host. The isolation of pathogen-specific T cells from a healthy donor and their infusion into a recipient is done by a procedure known as adoptive T-cell transfer. The separation of pathogenspecific T cells is necessary to deplete alloreactive T cells and avoid graft-versus-host disease. Adoptive T-cell transfer has been performed after allogeneic SCT in many patients with CMV, EBV, and ADV infections using time-and labour-consuming protocols. Based on basic research, new immunotherapeutic protocols aim at a broader and faster availability of adoptive T-cell transfer. However, the manipulation of antigen-specific T-cell responses as a treatment approach remains an ongoing challenge.

Translated title of the contributionInfections after allogeneic stem cell transplantation. Treatment by adoptive transfer of antigen-specific T cells
Original languageGerman
Pages (from-to)246-253
Number of pages8
JournalMonatsschrift fur Kinderheilkunde
Volume158
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

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