Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland

H. Shen; K. M. Main; A. M. Andersson; I. N. Damgaard; H. E. Virtanen; N. E. Skakkebaek; J. Toppari; K. W. Schramm

doi:10.2495/ETOX080051

Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland

H. Shen
, K. M. Main
, A. M. Andersson
, I. N. Damgaard
, H. E. Virtanen
, N. E. Skakkebaek
, J. Toppari
, K. W. Schramm

Life Sciences

Helmholtz Zentrum München German Research Center for Environmental Health
Rigshospitalet
University of Turku and Turku University Hospital

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.

Original language	English
Title of host publication	Environmental Toxicology II
Publisher	WITPress
Pages	45-52
Number of pages	8
Volume	110
ISBN (Print)	9781845641146
DOIs	https://doi.org/10.2495/ETOX080051
State	Published - 2008
Event	2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008 - Granada, Portugal Duration: 4 Jun 2008 → 6 Jun 2008

Conference

Conference	2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008
Country/Territory	Portugal
City	Granada
Period	4/06/08 → 6/06/08

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast milk
Infants
Organobromine compounds
Organochlorine pesticides
Placenta

Access to Document

10.2495/ETOX080051

Cite this

@inproceedings{703d1e14d2c848078ab6e9e04c73b93b,

title = "Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland",

abstract = "Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.",

keywords = "Breast milk, Infants, Organobromine compounds, Organochlorine pesticides, Placenta",

author = "H. Shen and Main, \{K. M.\} and Andersson, \{A. M.\} and Damgaard, \{I. N.\} and Virtanen, \{H. E.\} and Skakkebaek, \{N. E.\} and J. Toppari and Schramm, \{K. W.\}",

year = "2008",

doi = "10.2495/ETOX080051",

language = "English",

isbn = "9781845641146",

volume = "110",

pages = "45--52",

booktitle = "Environmental Toxicology II",

publisher = "WITPress",

note = "2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008 ; Conference date: 04-06-2008 Through 06-06-2008",

}

Shen, H, Main, KM, Andersson, AM, Damgaard, IN, Virtanen, HE, Skakkebaek, NE, Toppari, J & Schramm, KW 2008, Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland. in Environmental Toxicology II. vol. 110, WITPress, pp. 45-52, 2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008, Granada, Portugal, 4/06/08. https://doi.org/10.2495/ETOX080051

TY - GEN

T1 - Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland

AU - Shen, H.

AU - Main, K. M.

AU - Andersson, A. M.

AU - Damgaard, I. N.

AU - Virtanen, H. E.

AU - Skakkebaek, N. E.

AU - Toppari, J.

AU - Schramm, K. W.

PY - 2008

Y1 - 2008

N2 - Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.

AB - Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.

KW - Breast milk

KW - Infants

KW - Organobromine compounds

KW - Organochlorine pesticides

KW - Placenta

UR - https://www.scopus.com/pages/publications/58849095393

U2 - 10.2495/ETOX080051

DO - 10.2495/ETOX080051

M3 - Conference contribution

AN - SCOPUS:58849095393

SN - 9781845641146

VL - 110

SP - 45

EP - 52

BT - Environmental Toxicology II

PB - WITPress

T2 - 2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008

Y2 - 4 June 2008 through 6 June 2008

ER -

Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland

Abstract

Conference

UN SDGs

Keywords

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