Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines

M. Göttlicher; P. Cikryt

doi:10.1093/carcin/8.7.1021

Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines

M. Göttlicher, P. Cikryt

University of Würzburg

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminopbenanthrene (AAP) and trans-4-acetyl-aminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF and MC did not alter significantly the hepatic receptor concentration. In contrast, the strong liver tumor initiator AAS doubled the hepatic Ah receptor level when a dose of 20 μmol/kg was administered for 5 days. AAP increased the amount of the receptor 1.5-fold.

Original language	English
Pages (from-to)	1021-1023
Number of pages	3
Journal	Carcinogenesis
Volume	8
Issue number	7
DOIs	https://doi.org/10.1093/carcin/8.7.1021
State	Published - Jul 1987
Externally published	Yes

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10.1093/carcin/8.7.1021

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title = "Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines",

abstract = "The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminopbenanthrene (AAP) and trans-4-acetyl-aminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF and MC did not alter significantly the hepatic receptor concentration. In contrast, the strong liver tumor initiator AAS doubled the hepatic Ah receptor level when a dose of 20 μmol/kg was administered for 5 days. AAP increased the amount of the receptor 1.5-fold.",

author = "M. G{\"o}ttlicher and P. Cikryt",

note = "Funding Information: We thank Dr H.-G.Neumann for critically reading the manuscript and for helpful suggestions. The expert technical assistance of Mrs Bngitte Hasemann is gratefully acknowledged. The work was supported by grants from the Deutsche Forschungs-gemeinschaft (Sonderforschungsbereich 172 'Molekulare Mechanismen kanzerogener PrimarlSsionen').",

year = "1987",

month = jul,

doi = "10.1093/carcin/8.7.1021",

language = "English",

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T1 - Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines

AU - Göttlicher, M.

AU - Cikryt, P.

N1 - Funding Information: We thank Dr H.-G.Neumann for critically reading the manuscript and for helpful suggestions. The expert technical assistance of Mrs Bngitte Hasemann is gratefully acknowledged. The work was supported by grants from the Deutsche Forschungs-gemeinschaft (Sonderforschungsbereich 172 'Molekulare Mechanismen kanzerogener PrimarlSsionen').

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N2 - The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminopbenanthrene (AAP) and trans-4-acetyl-aminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF and MC did not alter significantly the hepatic receptor concentration. In contrast, the strong liver tumor initiator AAS doubled the hepatic Ah receptor level when a dose of 20 μmol/kg was administered for 5 days. AAP increased the amount of the receptor 1.5-fold.

AB - The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminopbenanthrene (AAP) and trans-4-acetyl-aminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF and MC did not alter significantly the hepatic receptor concentration. In contrast, the strong liver tumor initiator AAS doubled the hepatic Ah receptor level when a dose of 20 μmol/kg was administered for 5 days. AAP increased the amount of the receptor 1.5-fold.

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JO - Carcinogenesis

JF - Carcinogenesis

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ER -

Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines

Abstract

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