Induction of ornithine decarboxylase by aromatic amines in rat liver

M. Göttlicher; P. Cikryt

doi:10.1016/0304-3835(87)90057-7

Induction of ornithine decarboxylase by aromatic amines in rat liver

M. Göttlicher, P. Cikryt

University of Würzburg

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The induction of ornithine decarboxylase (ODC) in rat liver by the carcinogen 2-acetylaminofluorene (2AAF), the strong liver tumor initiator trans-4-acetylaminostilbene (AAS), the non-carcinogen 4-acetylaminofluorene (4AAF) and, as a control, 3-methylcholanthrene (MC) has been examined. MC and all aromatic amines increased the ODC activity of rat liver from 3.6-fold (MC) to maximal 5.7-fold (AAS). The time course of the maximal induction differs from 2.5 h (2AAF) to 10 h (MC). The cytosolic concentrations of the unchanged compounds parallel the ODC activity. These data indicate that ODC induction in rat liver shows no correlation with tumor promoting properties of the model compounds. It is concluded that the unchanged compound is responsible for the ODC induction.

Original language	English
Pages (from-to)	65-70
Number of pages	6
Journal	Cancer Letters
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(87)90057-7
State	Published - Apr 1987
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0304-3835(87)90057-7

Cite this

@article{d7f8cf660a884091a422261dba49a1ab,

title = "Induction of ornithine decarboxylase by aromatic amines in rat liver",

abstract = "The induction of ornithine decarboxylase (ODC) in rat liver by the carcinogen 2-acetylaminofluorene (2AAF), the strong liver tumor initiator trans-4-acetylaminostilbene (AAS), the non-carcinogen 4-acetylaminofluorene (4AAF) and, as a control, 3-methylcholanthrene (MC) has been examined. MC and all aromatic amines increased the ODC activity of rat liver from 3.6-fold (MC) to maximal 5.7-fold (AAS). The time course of the maximal induction differs from 2.5 h (2AAF) to 10 h (MC). The cytosolic concentrations of the unchanged compounds parallel the ODC activity. These data indicate that ODC induction in rat liver shows no correlation with tumor promoting properties of the model compounds. It is concluded that the unchanged compound is responsible for the ODC induction.",

author = "M. G{\"o}ttlicher and P. Cikryt",

year = "1987",

month = apr,

doi = "10.1016/0304-3835(87)90057-7",

language = "English",

volume = "35",

pages = "65--70",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Induction of ornithine decarboxylase by aromatic amines in rat liver

AU - Göttlicher, M.

AU - Cikryt, P.

PY - 1987/4

Y1 - 1987/4

N2 - The induction of ornithine decarboxylase (ODC) in rat liver by the carcinogen 2-acetylaminofluorene (2AAF), the strong liver tumor initiator trans-4-acetylaminostilbene (AAS), the non-carcinogen 4-acetylaminofluorene (4AAF) and, as a control, 3-methylcholanthrene (MC) has been examined. MC and all aromatic amines increased the ODC activity of rat liver from 3.6-fold (MC) to maximal 5.7-fold (AAS). The time course of the maximal induction differs from 2.5 h (2AAF) to 10 h (MC). The cytosolic concentrations of the unchanged compounds parallel the ODC activity. These data indicate that ODC induction in rat liver shows no correlation with tumor promoting properties of the model compounds. It is concluded that the unchanged compound is responsible for the ODC induction.

AB - The induction of ornithine decarboxylase (ODC) in rat liver by the carcinogen 2-acetylaminofluorene (2AAF), the strong liver tumor initiator trans-4-acetylaminostilbene (AAS), the non-carcinogen 4-acetylaminofluorene (4AAF) and, as a control, 3-methylcholanthrene (MC) has been examined. MC and all aromatic amines increased the ODC activity of rat liver from 3.6-fold (MC) to maximal 5.7-fold (AAS). The time course of the maximal induction differs from 2.5 h (2AAF) to 10 h (MC). The cytosolic concentrations of the unchanged compounds parallel the ODC activity. These data indicate that ODC induction in rat liver shows no correlation with tumor promoting properties of the model compounds. It is concluded that the unchanged compound is responsible for the ODC induction.

UR - http://www.scopus.com/inward/record.url?scp=0023105569&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(87)90057-7

DO - 10.1016/0304-3835(87)90057-7

M3 - Article

C2 - 3567888

AN - SCOPUS:0023105569

SN - 0304-3835

VL - 35

SP - 65

EP - 70

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Induction of ornithine decarboxylase by aromatic amines in rat liver

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this