Abstract
Hydroxyurea induces repair replication in human lymphoblastoid NC37 BaEV cells during incubation with liver microsomes and NADPH. Catalase reduces hydroxyurea-induced repair by more than 95%, suggesting that hydrogen peroxide derived from hydroxyurea in the presence of the metabolic activation system is involved in the DNA damage.
| Original language | English |
|---|---|
| Pages (from-to) | 50-58 |
| Number of pages | 9 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 87 |
| Issue number | 1 |
| DOIs | |
| State | Published - 15 Mar 1979 |
| Externally published | Yes |