Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer

Michael S. Kobrin; Hitoshi Funatomi; Helmut Friess; Markus W. Buchler; Peter Stathis; Murray Korc

doi:10.1006/bbrc.1994.2131

Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer

Michael S. Kobrin, Hitoshi Funatomi, Helmut Friess, Markus W. Buchler, Peter Stathis, Murray Korc

Research output: Contribution to journal › Article › peer-review

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Abstract

Heparin-binding EGF-like growth factor (HB-EGF) is a polypeptide with an apparent molecular weight of 22 kilodalton that is related to epidermal growth factor (EGF) and that binds and activates the EGF receptor. We examined HB-EGF biological action and expression in human pancreatic cancer cell lines, and compared HB-EGF expression in normal and cancerous pancreatic tissues. HB-EGF enhanced the growth of human pancreatic cancer cells in a dose-dependent manner. Several cell lines expressed HB-EGF mRNA transcripts, and the transcript level was enhanced by HB-EGF, as well as by 12-O-tetradecanoylphorbol-13-acetate and transforming growth factor-alpha (TGF-α). By comparison with the normal pancreas, HB-EGF mRNA levels were increased in human pancreatic cancer tissues. These findings suggest that HB-EGF may participate in aberrant autocrine and paracrine activation of the EGF receptor, thereby contributing to pancreatic cancer cell growth.

Original language	English
Pages (from-to)	1705-1709
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	202
Issue number	3
DOIs	https://doi.org/10.1006/bbrc.1994.2131
State	Published - 15 Aug 1994
Externally published	Yes

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title = "Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer",

abstract = "Heparin-binding EGF-like growth factor (HB-EGF) is a polypeptide with an apparent molecular weight of 22 kilodalton that is related to epidermal growth factor (EGF) and that binds and activates the EGF receptor. We examined HB-EGF biological action and expression in human pancreatic cancer cell lines, and compared HB-EGF expression in normal and cancerous pancreatic tissues. HB-EGF enhanced the growth of human pancreatic cancer cells in a dose-dependent manner. Several cell lines expressed HB-EGF mRNA transcripts, and the transcript level was enhanced by HB-EGF, as well as by 12-O-tetradecanoylphorbol-13-acetate and transforming growth factor-alpha (TGF-α). By comparison with the normal pancreas, HB-EGF mRNA levels were increased in human pancreatic cancer tissues. These findings suggest that HB-EGF may participate in aberrant autocrine and paracrine activation of the EGF receptor, thereby contributing to pancreatic cancer cell growth.",

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AU - Funatomi, Hitoshi

AU - Friess, Helmut

AU - Buchler, Markus W.

AU - Stathis, Peter

AU - Korc, Murray

PY - 1994/8/15

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AB - Heparin-binding EGF-like growth factor (HB-EGF) is a polypeptide with an apparent molecular weight of 22 kilodalton that is related to epidermal growth factor (EGF) and that binds and activates the EGF receptor. We examined HB-EGF biological action and expression in human pancreatic cancer cell lines, and compared HB-EGF expression in normal and cancerous pancreatic tissues. HB-EGF enhanced the growth of human pancreatic cancer cells in a dose-dependent manner. Several cell lines expressed HB-EGF mRNA transcripts, and the transcript level was enhanced by HB-EGF, as well as by 12-O-tetradecanoylphorbol-13-acetate and transforming growth factor-alpha (TGF-α). By comparison with the normal pancreas, HB-EGF mRNA levels were increased in human pancreatic cancer tissues. These findings suggest that HB-EGF may participate in aberrant autocrine and paracrine activation of the EGF receptor, thereby contributing to pancreatic cancer cell growth.

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Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer

Abstract

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