Induction and effector functions of TH17 cells

Estelle Bettelli; Thomas Korn; Mohamed Oukka; Vijay K. Kuchroo

doi:10.1038/nature07036

Induction and effector functions of T_H17 cells

Estelle Bettelli, Thomas Korn, Mohamed Oukka, Vijay K. Kuchroo

Research output: Contribution to journal › Review article › peer-review

1043 Scopus citations

Abstract

T helper (T_H) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered T_H17 cells, the third subset of effector T helper cells, have been the subject of intense research aimed at understanding their role in immunity and disease. Here we review emerging data suggesting that T_H17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (T_reg) cells, which prevent tissue inflammation and mediate self-tolerance.

Original language	English
Pages (from-to)	1051-1057
Number of pages	7
Journal	Nature
Volume	453
Issue number	7198
DOIs	https://doi.org/10.1038/nature07036
State	Published - 19 Jun 2008
Externally published	Yes

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title = "Induction and effector functions of TH17 cells",

abstract = "T helper (TH) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered TH17 cells, the third subset of effector T helper cells, have been the subject of intense research aimed at understanding their role in immunity and disease. Here we review emerging data suggesting that TH17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (Treg) cells, which prevent tissue inflammation and mediate self-tolerance.",

author = "Estelle Bettelli and Thomas Korn and Mohamed Oukka and Kuchroo, {Vijay K.}",

note = "Funding Information: Acknowledgements This work was supported by grants from the National Multiple Sclerosis Society, the National Institutes of Health, the Juvenile Diabetes Research Foundation Center for Immunological Tolerance at Harvard, and the Deutsche Forschungsgemeinschaft. V.K.K. is the recipient of the Javits Neuroscience Investigator Award from the National Institutes of Health.",

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AU - Bettelli, Estelle

AU - Korn, Thomas

AU - Oukka, Mohamed

AU - Kuchroo, Vijay K.

N1 - Funding Information: Acknowledgements This work was supported by grants from the National Multiple Sclerosis Society, the National Institutes of Health, the Juvenile Diabetes Research Foundation Center for Immunological Tolerance at Harvard, and the Deutsche Forschungsgemeinschaft. V.K.K. is the recipient of the Javits Neuroscience Investigator Award from the National Institutes of Health.

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N2 - T helper (TH) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered TH17 cells, the third subset of effector T helper cells, have been the subject of intense research aimed at understanding their role in immunity and disease. Here we review emerging data suggesting that TH17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (Treg) cells, which prevent tissue inflammation and mediate self-tolerance.

AB - T helper (TH) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered TH17 cells, the third subset of effector T helper cells, have been the subject of intense research aimed at understanding their role in immunity and disease. Here we review emerging data suggesting that TH17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (Treg) cells, which prevent tissue inflammation and mediate self-tolerance.

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Induction and effector functions of T_H17 cells

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