Induced pluripotent stem cells in regenerative medicine

Luna Simona Pane, Ilaria My, Alessandra Moretti

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


The conversion of somatic cells into pluripotent cells is transforming the way diseases are studied and treated. Owing to their ability to differentiate into any cell type in the body and being patient-specific, induced pluripotent stem cells (iPSCs) hold great promise for disease modeling, drug discovery and regenerative medicine. Since their discovery in 2006, significant efforts have been made to understand the reprogramming process and to generate human iPSCs with potential for clinical use. Additionally, the development of advanced genome-editing platforms to increase homologous recombination efficiency, namely DNA nucleases, is making the generation of gene-corrected patient-specific iPSCs an achievable goal, with potential future therapeutic applications. Here, we review recent developments in the generation, differentiation and genetic manipulation of human iPSCs and discuss their relevance to regenerative medicine and the challenges still remaining for clinical application.

Original languageEnglish
Title of host publicationRegenerative Medicine - from Protocol to Patient
Subtitle of host publication2. Stem Cell Science and Technology: Third Edition
PublisherSpringer International Publishing
Number of pages25
ISBN (Electronic)9783319276106
ISBN (Print)9783319276083
StatePublished - 19 Apr 2016
Externally publishedYes


  • Cardiac differentiation
  • Induced pluripotent stem cells
  • Lentivirus
  • Macula degeneration
  • Piggybac transposase
  • Reprogramming
  • Retrovirus
  • Targeting vector
  • Transduction
  • Zero-footprint method


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