Individual Correspondence of Amyloid-β and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease

Lorenzo Pasquini, Gloria Benson, Michel J. Grothe, Lukas Utz, Nicholas E. Myers, Igor Yakushev, Timo Grimmer, Martin Scherr, Christian Sorg

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

In Alzheimer's disease (AD), amyloid-β (Aβ) pathology and intrinsic functional connectivity (iFC) interact. Across stages of AD, we expected individual spatial correspondence of Aβ and iFC to reveal both Aβ accumulation and its detrimental effects on iFC. We used resting-state functional magnetic imaging and Aβ imaging in a cross-sectional sample of 90 subjects across stages of AD and healthy older adults. Global and local correspondence of Aβ and iFC were assessed within the posterior default mode network (pDMN) by within-subject voxel-wise correlations. Beginning at preclinical stages, global Aβ-iFC correspondence was positive for the whole pDMN, showing that Aβ accumulates in areas of high connectivity, and reached a plateau at prodromal stages. Starting at preclinical stages, local correspondence was negative in network centers, indicating that Aβ reduces connectivity of the pDMN as a function of local plaque concentration, and peaked at prodromal stages. Positive global correspondence suggests that Aβ accumulation progresses along iFC, with this effect starting in preclinical stages, and being constant along clinical periods. Negative local correspondence suggests detrimental effects of Aβ on iFC in network centers, starting at preclinical stages, and peaking when first symptoms appear. Data reveal a complex trajectory of Aβ and iFC correspondence, affecting both Aβ accumulation and iFC impairments.

Original languageEnglish
Pages (from-to)763-773
Number of pages11
JournalJournal of Alzheimer's Disease
Volume58
Issue number3
DOIs
StatePublished - 2017

Keywords

  • Alzheimer's disease
  • amyloid-β
  • intrinsic functional connectivity
  • mild cognitive impairment
  • multimodal imaging

Fingerprint

Dive into the research topics of 'Individual Correspondence of Amyloid-β and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease'. Together they form a unique fingerprint.

Cite this