Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis

Lisa Bast; Filippo Calzolari; Michael K. Strasser; Jan Hasenauer; Fabian J. Theis; Jovica Ninkovic; Carsten Marr

doi:10.1016/j.celrep.2018.11.088

Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis

Lisa Bast, Filippo Calzolari, Michael K. Strasser, Jan Hasenauer, Fabian J. Theis, Jovica Ninkovic, Carsten Marr

Chair of Mathematical Modelling of Biological Systems

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Bast and colleagues traced the lineages of single neural stem cells in the brains of young and aged adult mice to shed light on the age-related decline in neurogenesis. Mathematical modeling of lineage dynamics revealed changes in the behavior of neural stem cells with age.

Original language	English
Pages (from-to)	3231-3240.e8
Journal	Cell Reports
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2018.11.088
State	Published - 18 Dec 2018

Keywords

adult neurogenesis
computational model
lineage tracing
lineage tree simulation
model averaging
moment equations

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10.1016/j.celrep.2018.11.088

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title = "Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis",

abstract = "Bast and colleagues traced the lineages of single neural stem cells in the brains of young and aged adult mice to shed light on the age-related decline in neurogenesis. Mathematical modeling of lineage dynamics revealed changes in the behavior of neural stem cells with age.",

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author = "Lisa Bast and Filippo Calzolari and Strasser, {Michael K.} and Jan Hasenauer and Theis, {Fabian J.} and Jovica Ninkovic and Carsten Marr",

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AU - Strasser, Michael K.

AU - Hasenauer, Jan

AU - Theis, Fabian J.

AU - Ninkovic, Jovica

AU - Marr, Carsten

PY - 2018/12/18

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KW - computational model

KW - lineage tracing

KW - lineage tree simulation

KW - model averaging

KW - moment equations

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Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis

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Keywords

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