Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity

Felix S. Krause, Alexander Henrich, Bastian Blombach, Reinhard Krämer, Bernhard J. Eikmanns, Gerd M. Seibold

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Corynebacterium glutamicum efficiently utilizes maltose as a substrate. We show here that the presence of maltose increases glucose utilization by raising the expression of ptsG, which encodes the glucose-specific EII permease of the phosphotransferase system. Consequently, the L-valine productivity of a pyruvate dehydrogenase complex-deficient C. glutamicum strain was improved by the presence of maltose.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalApplied and Environmental Microbiology
Volume76
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

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