Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity

Felix S. Krause; Alexander Henrich; Bastian Blombach; Reinhard Krämer; Bernhard J. Eikmanns; Gerd M. Seibold

doi:10.1128/AEM.01553-09

Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity

Felix S. Krause, Alexander Henrich, Bastian Blombach, Reinhard Krämer, Bernhard J. Eikmanns, Gerd M. Seibold

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Corynebacterium glutamicum efficiently utilizes maltose as a substrate. We show here that the presence of maltose increases glucose utilization by raising the expression of ptsG, which encodes the glucose-specific EII permease of the phosphotransferase system. Consequently, the L-valine productivity of a pyruvate dehydrogenase complex-deficient C. glutamicum strain was improved by the presence of maltose.

Original language	English
Pages (from-to)	370-374
Number of pages	5
Journal	Applied and Environmental Microbiology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1128/AEM.01553-09
State	Published - Jan 2010
Externally published	Yes

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abstract = "Corynebacterium glutamicum efficiently utilizes maltose as a substrate. We show here that the presence of maltose increases glucose utilization by raising the expression of ptsG, which encodes the glucose-specific EII permease of the phosphotransferase system. Consequently, the L-valine productivity of a pyruvate dehydrogenase complex-deficient C. glutamicum strain was improved by the presence of maltose.",

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AU - Krämer, Reinhard

AU - Eikmanns, Bernhard J.

AU - Seibold, Gerd M.

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AB - Corynebacterium glutamicum efficiently utilizes maltose as a substrate. We show here that the presence of maltose increases glucose utilization by raising the expression of ptsG, which encodes the glucose-specific EII permease of the phosphotransferase system. Consequently, the L-valine productivity of a pyruvate dehydrogenase complex-deficient C. glutamicum strain was improved by the presence of maltose.

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Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity

Abstract

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