TY - JOUR
T1 - Incorporation of Controlled Release Systems Improves the Functionality of Biodegradable 3D Printed Cardiovascular Implants
AU - Kabirian, Fatemeh
AU - Mozafari, Masoud
AU - Mela, Petra
AU - Heying, Ruth
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/11/13
Y1 - 2023/11/13
N2 - New horizons in cardiovascular research are opened by using 3D printing for biodegradable implants. This additive manufacturing approach allows the design and fabrication of complex structures according to the patient’s imaging data in an accurate, reproducible, cost-effective, and quick manner. Acellular cardiovascular implants produced from biodegradable materials have the potential to provide enough support for in situ tissue regeneration while gradually being replaced by neo-autologous tissue. Subsequently, they have the potential to prevent long-term complications. In this Review, we discuss the current status of 3D printing applications in the development of biodegradable cardiovascular implants with a focus on design, biomaterial selection, fabrication methods, and advantages of implantable controlled release systems. Moreover, we delve into the intricate challenges that accompany the clinical translation of these groundbreaking innovations, presenting a glimpse of potential solutions poised to enable the realization of these technologies in the realm of cardiovascular medicine.
AB - New horizons in cardiovascular research are opened by using 3D printing for biodegradable implants. This additive manufacturing approach allows the design and fabrication of complex structures according to the patient’s imaging data in an accurate, reproducible, cost-effective, and quick manner. Acellular cardiovascular implants produced from biodegradable materials have the potential to provide enough support for in situ tissue regeneration while gradually being replaced by neo-autologous tissue. Subsequently, they have the potential to prevent long-term complications. In this Review, we discuss the current status of 3D printing applications in the development of biodegradable cardiovascular implants with a focus on design, biomaterial selection, fabrication methods, and advantages of implantable controlled release systems. Moreover, we delve into the intricate challenges that accompany the clinical translation of these groundbreaking innovations, presenting a glimpse of potential solutions poised to enable the realization of these technologies in the realm of cardiovascular medicine.
KW - 3D printing
KW - additive manufacturing
KW - clinical translation
KW - controlled release system
KW - drug delivery
KW - heart valve
KW - regulatory challenges
KW - vascular graft
KW - vascular stent
UR - http://www.scopus.com/inward/record.url?scp=85176969434&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.3c00559
DO - 10.1021/acsbiomaterials.3c00559
M3 - Review article
C2 - 37856240
AN - SCOPUS:85176969434
SN - 2373-9878
VL - 9
SP - 5953
EP - 5967
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 11
ER -