Incidental postmortem diagnosis of DIPNECH in a patient with previously unexplained 'asthma bronchiale'

Albrecht Stenzinger, Wilko Weichert, Mario Hensel, Holger Bruns, Manfred Dietel, Andreas Erbersdobler

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We report the case of a 69-year-old female patient with a progressively worsening, clinically unexplained symptomatic asthma bronchiale who eventually died due to urosepsis. A subsequent autopsy revealed diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH), a very rare preneoplastic disease of the pulmonary neuroendocrine cell system, as the cause of asthma bronchiale in our patient. We hypothesize that DIPNECH may be an underestimated cause of obstructive lung disease in a certain subset of patients. Therefore, studies are warranted to obtain statistically reliable demographic and clinical data of this pulmonary condition.Moreover, this case strongly argues for the relevance and significance of non-forensic autopsies in the clinical setting.

Original languageEnglish
Pages (from-to)785-787
Number of pages3
JournalPathology Research and Practice
Issue number11
StatePublished - 15 Nov 2010
Externally publishedYes


  • Bronchial asthma
  • Diffuse idiopathic pulmonary neuroendocrince cell hyperplasia
  • Lung


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