Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

Moran Amit; Yoav Binenbaum; Kanika Sharma; Naomi Ramer; Ilana Ramer; Abib Agbetoba; Joelle Glick; Xinjie Yang; Delin Lei; Kristine Bjørndal; Christian Godballe; Thomas Mücke; Klaus Dietrich Wolff; Dan Fliss; André M. Eckardt; Chiara Copelli; Enrico Sesenna; Frank Palmer; Ian Ganly; Snehal Patel; Ziv Gil

doi:10.1002/hed.23711

Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

Moran Amit, Yoav Binenbaum, Kanika Sharma, Naomi Ramer, Ilana Ramer, Abib Agbetoba, Joelle Glick, Xinjie Yang, Delin Lei, Kristine Bjørndal, Christian Godballe, Thomas Mücke, Klaus Dietrich Wolff, Dan Fliss, André M. Eckardt, Chiara Copelli, Enrico Sesenna, Frank Palmer, Ian Ganly, Snehal PatelZiv Gil

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Background The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. Methods We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. Results The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p =.001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p =.017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. Conclusion Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity.

Original language	English
Pages (from-to)	1032-1037
Number of pages	6
Journal	Head and Neck
Volume	37
Issue number	7
DOIs	https://doi.org/10.1002/hed.23711
State	Published - 1 Jul 2015
Externally published	Yes

Keywords

adenoid cystic carcinoma
incidence
lymph node
metastasis
survival

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Amit, M., Binenbaum, Y., Sharma, K., Ramer, N., Ramer, I., Agbetoba, A., Glick, J., Yang, X., Lei, D., Bjørndal, K., Godballe, C., Mücke, T., Wolff, K. D., Fliss, D., Eckardt, A. M., Copelli, C., Sesenna, E., Palmer, F., Ganly, I., ... Gil, Z. (2015). Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study. Head and Neck, 37(7), 1032-1037. https://doi.org/10.1002/hed.23711

@article{a7d503ca0d884993987d1a7c6a98bce7,

title = "Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study",

abstract = "Background The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. Methods We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. Results The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p =.001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p =.017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. Conclusion Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity.",

keywords = "adenoid cystic carcinoma, incidence, lymph node, metastasis, survival",

author = "Moran Amit and Yoav Binenbaum and Kanika Sharma and Naomi Ramer and Ilana Ramer and Abib Agbetoba and Joelle Glick and Xinjie Yang and Delin Lei and Kristine Bj{\o}rndal and Christian Godballe and Thomas M{\"u}cke and Wolff, {Klaus Dietrich} and Dan Fliss and Eckardt, {Andr{\'e} M.} and Chiara Copelli and Enrico Sesenna and Frank Palmer and Ian Ganly and Snehal Patel and Ziv Gil",

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year = "2015",

month = jul,

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doi = "10.1002/hed.23711",

language = "English",

volume = "37",

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Amit, M, Binenbaum, Y, Sharma, K, Ramer, N, Ramer, I, Agbetoba, A, Glick, J, Yang, X, Lei, D, Bjørndal, K, Godballe, C, Mücke, T, Wolff, KD, Fliss, D, Eckardt, AM, Copelli, C, Sesenna, E, Palmer, F, Ganly, I, Patel, S & Gil, Z 2015, 'Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study', Head and Neck, vol. 37, no. 7, pp. 1032-1037. https://doi.org/10.1002/hed.23711

TY - JOUR

T1 - Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

AU - Amit, Moran

AU - Binenbaum, Yoav

AU - Sharma, Kanika

AU - Ramer, Naomi

AU - Ramer, Ilana

AU - Agbetoba, Abib

AU - Glick, Joelle

AU - Yang, Xinjie

AU - Lei, Delin

AU - Bjørndal, Kristine

AU - Godballe, Christian

AU - Mücke, Thomas

AU - Wolff, Klaus Dietrich

AU - Fliss, Dan

AU - Eckardt, André M.

AU - Copelli, Chiara

AU - Sesenna, Enrico

AU - Palmer, Frank

AU - Ganly, Ian

AU - Patel, Snehal

AU - Gil, Ziv

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. Methods We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. Results The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p =.001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p =.017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. Conclusion Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity.

AB - Background The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. Methods We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. Results The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p =.001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p =.017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. Conclusion Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity.

KW - adenoid cystic carcinoma

KW - incidence

KW - lymph node

KW - metastasis

KW - survival

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DO - 10.1002/hed.23711

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AN - SCOPUS:84931570833

SN - 1043-3074

VL - 37

SP - 1032

EP - 1037

JO - Head and Neck

JF - Head and Neck

IS - 7

ER -

Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

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Keywords

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