TY - JOUR
T1 - Incidence and risk factors of respiratory syncytial virus-related hospitalizations in premature infants in Germany
AU - Liese, Johannes G.
AU - Grill, Eva
AU - Fischer, Birgit
AU - Roeckl-Wiedmann, Irmgard
AU - Carr, David
AU - Belohradsky, Bernd H.
AU - Münch, G.
AU - Simbruner, G.
AU - Küster, H.
AU - Lipowsky, G.
AU - Schulze, A.
AU - Genzel, O.
AU - Roos, R.
AU - Grimberg, B.
AU - Zimmermann, A.
AU - Der Isar, Klinkum Rechts
AU - Engelsberger, I.
AU - Peters, J.
AU - Kumlien, B.
AU - Daunderer,
AU - John, W.
AU - Peller, P.
AU - Andrian, H. C.
AU - Schenk, W.
N1 - Funding Information:
The study was supported by an unrestricted grant from Abbott Laboratories, Germany Members of the Munich RSV Study group: Münch G, Simbruner G, Universitäts-Kinderklinik im Dr. von Haunerschen Kinderspi-tal, Ludwig-Maximilians-Universität München, Germany; Küster H, Lipowsky G, 1.Universitäts-Frauenklinik, Ludwig-Maximil-ians-Universität, München, Germany; Schulze A, Genzel O, Klinikum Großhadern, Ludwig-Maximilians-Universität, Münch-en, Germany; Roos R, Grimberg B, Kinderklinik im Städtisches Krankenhaus Harlaching, München, Germany; Zimmermann A, Klinkum Rechts der Isar, Technische Universität, München, Germany; Engelsberger I, Peters J, Kinderklinik Schwabing, Techni-sche Universität, München, Germany; Kumlien B, Daunderer, Kinderklinik an der Lachnerstraße, München , Germany; John W, Peller P, Kinderklinik Klinikum Rosenheim, Germany; v. Andrian HC, Schenk W, Klinikum Augsburg, Germany J.G. Liese (&) Æ B. Fischer Æ D. Carr Æ B.H. Belohradsky University Children’s Hospital Munich, Ludwig-Maximilians-Universität, Lindwurmstr. 4, 80337 München, Germany Tel.: +49-89-51602811 or +49-89-51603120 Fax: +49-89-51602951
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Premature infants have an increased risk of developing complicated respiratory syncytial virus (RSV) infections. Epidemiological data on RSV-related hospitalizations are a prerequisite to develop guidelines for the use of preventive measures. The objective of this study was to determine incidence and risk factors of RSV-related rehospitalizations (RSV-RH) of premature infants. We recruited 1,103 infants with a gestational age of less than 35 weeks, primarily admitted to nine neonatologic care units in southern Germany between Nov. 1, 1998 and Oct. 31, 1999. Questionnaires were sent to all parents of infants discharged from neonatal care units to determine the risk of rehospitalization for acute respiratory infections (ARI-RH) and RSV-RH in the 1999-2000 season. The questionnaire response rate was 68.4%. The 717 included infants of the responders had a mean gestational age of 31.6 weeks (Range: 23-35) and a mean birth weight of 1,747 g (range: 430-4,050 g). The risk for an ARI-RH was 10.6% and the risk for RSVRH 5.2% during the observation period. Premature infants with chronic lung disease (CLD) had a probability of 24.5% for ARI-RH and of 15% for RSV-RH. The following factors were independently associated with an increased risk of RSV-RH: male gender (adjusted OddsRatio (OR): 8.7; 95% confidence interval (CI): 2.629.1), chronic lung disease (OR: 3.99; 95% CI: 1.4-11.2), discharge between October and December (OR: 2.1; 95%CI: 0.99-4.4), day-care attendance of siblings (OR: 3.9; 95%CI: 1.9-8.3). Conclusions: The risk for RSV rehospitalization among premature infants discharged from neonatal care facilities in southern Germany was low. Additional risk factors and high costs of prophylaxis have to be considered when infants are selected for RSV prophylaxis using monoclonal antibodies.
AB - Premature infants have an increased risk of developing complicated respiratory syncytial virus (RSV) infections. Epidemiological data on RSV-related hospitalizations are a prerequisite to develop guidelines for the use of preventive measures. The objective of this study was to determine incidence and risk factors of RSV-related rehospitalizations (RSV-RH) of premature infants. We recruited 1,103 infants with a gestational age of less than 35 weeks, primarily admitted to nine neonatologic care units in southern Germany between Nov. 1, 1998 and Oct. 31, 1999. Questionnaires were sent to all parents of infants discharged from neonatal care units to determine the risk of rehospitalization for acute respiratory infections (ARI-RH) and RSV-RH in the 1999-2000 season. The questionnaire response rate was 68.4%. The 717 included infants of the responders had a mean gestational age of 31.6 weeks (Range: 23-35) and a mean birth weight of 1,747 g (range: 430-4,050 g). The risk for an ARI-RH was 10.6% and the risk for RSVRH 5.2% during the observation period. Premature infants with chronic lung disease (CLD) had a probability of 24.5% for ARI-RH and of 15% for RSV-RH. The following factors were independently associated with an increased risk of RSV-RH: male gender (adjusted OddsRatio (OR): 8.7; 95% confidence interval (CI): 2.629.1), chronic lung disease (OR: 3.99; 95% CI: 1.4-11.2), discharge between October and December (OR: 2.1; 95%CI: 0.99-4.4), day-care attendance of siblings (OR: 3.9; 95%CI: 1.9-8.3). Conclusions: The risk for RSV rehospitalization among premature infants discharged from neonatal care facilities in southern Germany was low. Additional risk factors and high costs of prophylaxis have to be considered when infants are selected for RSV prophylaxis using monoclonal antibodies.
KW - Hospitalization
KW - Premature infants
KW - Prevention
KW - Respiratory syncytial virus
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=0037387758&partnerID=8YFLogxK
U2 - 10.1007/s00431-002-1105-7
DO - 10.1007/s00431-002-1105-7
M3 - Article
C2 - 12647195
AN - SCOPUS:0037387758
SN - 0340-6199
VL - 162
SP - 230
EP - 236
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 4
ER -