Incidence and predictors of reCurrent restenosis after drug-coated balloon Angioplasty for Restenosis of a drUg-eluting Stent: The ICARUS Cooperation

Translated title of the contribution: Incidence and predictors of reCurrent restenosis after drug-coated balloon Angioplasty for Restenosis of a drUg-eluting Stent: The ICARUS Cooperation

Salvatore Cassese, Bo Xu, Seiji Habara, Harald Rittger, Robert A. Byrne, Matthias Waliszewski, María José Pérez-Vizcayno, Runlin Gao, Adnan Kastrati, Fernando Alfonso

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Introduction and objectives: The incidence and predictors of recurrent restenosis after drug-coated balloon (DCB) angioplasty for drug-eluting stent (DES) restenosis remain poorly studied. We sought to evaluate the incidence and predictors of recurrent restenosis among participants in randomized controlled trials receiving DCB angioplasty for DES restenosis. Methods: The clinical and lesion data of individuals enrolled in 6 randomized controlled trials of DCB angioplasty for DES restenosis were pooled. All patients included in this report were assigned to receive paclitaxel-coated balloon angioplasty with the SeQuent Please DCB (B Braun, Melsungen, Germany). The current analysis focused on participants with available follow-up angiography at 6 to 9 months. The incidence of recurrent restenosis, defined as diameter restenosis ≥ 50% in the in-segment area at follow-up angiography, and its clinical and angiographic predictors were evaluated. Results: A total of 546 patients were combined in a single dataset. Angiographic follow-up at 6 to 9 months was available for 484 patients (88.6%) with 518 treated lesions. Recurrent restenosis was detected in 101 (20.8%) patients. On multivariable analysis, lesion length (OR, 1.58; 95%CI, 1.10-2.26; P =.012 for 5 mm increase) and vessel size (OR, 1.42; 95%, 1.12-1.79; P =.003 for 0.5 mm reduction) were independently associated with recurrent restenosis. Conclusions: In the largest cohort to date of individuals with angiographic surveillance after DCB angioplasty for DES restenosis, we demonstrated that recurrent restenosis occurs in approximately 1 out of 5 patients. Predictors of recurrent restenosis are increased lesion length and small vessel size. Full English text available from: www.revespcardiol.org/en

Translated title of the contributionIncidence and predictors of reCurrent restenosis after drug-coated balloon Angioplasty for Restenosis of a drUg-eluting Stent: The ICARUS Cooperation
Original languageEnglish
Pages (from-to)620-627
Number of pages8
JournalRevista Espanola de Cardiologia
Volume71
Issue number8
DOIs
StatePublished - Aug 2018

Keywords

  • Angiography
  • Coronary artery disease
  • Drug-coated balloon
  • Drug-eluting stent
  • Restenosis

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