TY - JOUR
T1 - In-vivo X-ray Dark-Field Chest Radiography of a Pig
AU - Gromann, Lukas B.
AU - De Marco, Fabio
AU - Willer, Konstantin
AU - Noël, Peter B.
AU - Scherer, Kai
AU - Renger, Bernhard
AU - Gleich, Bernhard
AU - Achterhold, Klaus
AU - Fingerle, Alexander A.
AU - Muenzel, Daniela
AU - Auweter, Sigrid
AU - Hellbach, Katharina
AU - Reiser, Maximilian
AU - Baehr, Andrea
AU - Dmochewitz, Michaela
AU - Schroeter, Tobias J.
AU - Koch, Frieder J.
AU - Meyer, Pascal
AU - Kunka, Danays
AU - Mohr, Juergen
AU - Yaroshenko, Andre
AU - Maack, Hanns Ingo
AU - Pralow, Thomas
AU - Van Der Heijden, Hendrik
AU - Proksa, Roland
AU - Koehler, Thomas
AU - Wieberneit, Nataly
AU - Rindt, Karsten
AU - Rummeny, Ernst J.
AU - Pfeiffer, Franz
AU - Herzen, Julia
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the first in-vivo XDF full-field chest radiographs (32 × 35 cm2) of a living pig, acquired with clinically compatible parameters (40 s scan time, approx. 80 μSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.
AB - X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the first in-vivo XDF full-field chest radiographs (32 × 35 cm2) of a living pig, acquired with clinically compatible parameters (40 s scan time, approx. 80 μSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.
UR - http://www.scopus.com/inward/record.url?scp=85021887689&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-05101-w
DO - 10.1038/s41598-017-05101-w
M3 - Article
C2 - 28684858
AN - SCOPUS:85021887689
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 4807
ER -