TY - GEN
T1 - In vivo study of cross-sectional skeletal muscle fiber asymmetry with diffusion-weighted MRI
AU - Karampinos, Dimitrios C.
AU - King, Kevin F.
AU - Sutton, Brad P.
AU - Georgiadis, John G.
PY - 2007
Y1 - 2007
N2 - Skeletal muscles are highly organized hierarchical structures characterized by an anisotropic arrangement of muscle fibers (myocytes) in fascicles. Due to its unique non-invasive microstructure probing capabilities, diffusion-weighted Magnetic Resonance Imaging (DW-MRI) constitutes a valuable non-invasive tool in the study of such fibrous biological tissues. We have implemented a DW-MRI sequence with highly sensitive directional encoding to quantify the microarchitectural properties of human calf muscles at rest. We have specifically focused on a composite model-based analysis of diffusion tensor MRI measurements to quantify in vivo the cross-sectional asymmetry of muscle fiber geometry, which is a microstructural feature well documented in prior histological studies.
AB - Skeletal muscles are highly organized hierarchical structures characterized by an anisotropic arrangement of muscle fibers (myocytes) in fascicles. Due to its unique non-invasive microstructure probing capabilities, diffusion-weighted Magnetic Resonance Imaging (DW-MRI) constitutes a valuable non-invasive tool in the study of such fibrous biological tissues. We have implemented a DW-MRI sequence with highly sensitive directional encoding to quantify the microarchitectural properties of human calf muscles at rest. We have specifically focused on a composite model-based analysis of diffusion tensor MRI measurements to quantify in vivo the cross-sectional asymmetry of muscle fiber geometry, which is a microstructural feature well documented in prior histological studies.
UR - http://www.scopus.com/inward/record.url?scp=57649179504&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2007.4352290
DO - 10.1109/IEMBS.2007.4352290
M3 - Conference contribution
C2 - 18001956
AN - SCOPUS:57649179504
SN - 1424407885
SN - 9781424407880
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 327
EP - 330
BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Y2 - 23 August 2007 through 26 August 2007
ER -