TY - GEN
T1 - In-vivo MR imaging of lipoprotein distribution and metabolism using spio-labeled lipoproteins at 3T
AU - Ittrich, H.
AU - Bruns, O.
AU - Bartelt, A.
AU - Peldschus, K.
AU - Kaul, M. G.
AU - Adam, G.
AU - Heeren, J.
PY - 2013
Y1 - 2013
N2 - TRL-NS is a potent MR contrast agent with comparable properties to TRL. Dynamic in-vivo MR measurements after application of TRL-NS showed a two phase SNR change with a rapid exponential SNR decrease in order of vena cava, aorta, portal vein followed by a protracted SNR recovery in all vessels. Liver and BAT showed an exponential SNR decline (rΔSNRliver= -0.60±0.14 (p<0.01); rΔSNRBAT= -0.74±0.13 (p<0.01)) indicating high metabolism, that was confirmed with radioactive measurements. Skeletal muscle (rΔSNR= -0.08±0.18), myocardium (rΔSNR= -0.10±0.15) and WAT (rΔSNR= -0.05±0.11) showed a non-significant decline trend in contrast to significant uptake measured by y-counting. Brain showed no significant SNR changes in correlation to radioisotope counting. Corresponding to MR imaging histology and electron microscopy confirmed a predominantly accumulation of TRL-NS in liver and brown adipose tissue.
AB - TRL-NS is a potent MR contrast agent with comparable properties to TRL. Dynamic in-vivo MR measurements after application of TRL-NS showed a two phase SNR change with a rapid exponential SNR decrease in order of vena cava, aorta, portal vein followed by a protracted SNR recovery in all vessels. Liver and BAT showed an exponential SNR decline (rΔSNRliver= -0.60±0.14 (p<0.01); rΔSNRBAT= -0.74±0.13 (p<0.01)) indicating high metabolism, that was confirmed with radioactive measurements. Skeletal muscle (rΔSNR= -0.08±0.18), myocardium (rΔSNR= -0.10±0.15) and WAT (rΔSNR= -0.05±0.11) showed a non-significant decline trend in contrast to significant uptake measured by y-counting. Brain showed no significant SNR changes in correlation to radioisotope counting. Corresponding to MR imaging histology and electron microscopy confirmed a predominantly accumulation of TRL-NS in liver and brown adipose tissue.
UR - http://www.scopus.com/inward/record.url?scp=84881005789&partnerID=8YFLogxK
U2 - 10.1109/IWMPI.2013.6528361
DO - 10.1109/IWMPI.2013.6528361
M3 - Conference contribution
AN - SCOPUS:84881005789
SN - 9781467355223
T3 - 2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013
BT - 2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013
T2 - 2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013
Y2 - 23 March 2013 through 24 March 2013
ER -