TY - JOUR
T1 - In vivo imaging of the diseased nervous system
AU - Misgeld, Thomas
AU - Kerschensteiner, Martin
N1 - Funding Information:
We wish to express our gratitude to J. Lichtman for his mentorship and support. Our thanks also go to J. Sanes, H. Wekerle and R. Hohlfeld for continued support. J. Lichtman, R. Hohlfeld and L. Godinho made valuable suggestions after reading a previous version of this manuscript. Work in our laboratories is supported by the Christopher Reeve Paralysis Foundation, the ‘Brain-Immune Imaging Program’ of the Dana-Foundation, the ‘Emmy-Noether-Program’ of the Deutsche Forschungsgemeinschaft, and the ‘Verein Therapieforschung für MS-Kranke e.V.’ We acknowledge B. Engelhardt (University of Bern, Switzerland), D. Kleinfeld (University of California, San Diego, USA) and B. Hyman (Harvard Medical School, Boston, USA) for permission to reproduce figure material from their work, and apologize to colleagues whose work we had no space to cover.
PY - 2006/6
Y1 - 2006/6
N2 - In vivo microscopy is an exciting tool for neurological research because it can reveal how single cells respond to damage of the nervous system. This helps us to understand how diseases unfold and how therapies work. Here, we review the optical imaging techniques used to visualize the different parts of the nervous system, and how they have provided fresh insights into the aetiology and therapeutics of neurological diseases. We focus our discussion on five areas of neuropathology (trauma, degeneration, ischaemia, inflammation and seizures) in which in vivo microscopy has had the greatest impact. We discuss the challenging issues in the field, and argue that the convergence of new optical and non-optical methods will be necessary to overcome these challenges.
AB - In vivo microscopy is an exciting tool for neurological research because it can reveal how single cells respond to damage of the nervous system. This helps us to understand how diseases unfold and how therapies work. Here, we review the optical imaging techniques used to visualize the different parts of the nervous system, and how they have provided fresh insights into the aetiology and therapeutics of neurological diseases. We focus our discussion on five areas of neuropathology (trauma, degeneration, ischaemia, inflammation and seizures) in which in vivo microscopy has had the greatest impact. We discuss the challenging issues in the field, and argue that the convergence of new optical and non-optical methods will be necessary to overcome these challenges.
UR - http://www.scopus.com/inward/record.url?scp=33745740498&partnerID=8YFLogxK
U2 - 10.1038/nrn1905
DO - 10.1038/nrn1905
M3 - Review article
C2 - 16715054
AN - SCOPUS:33745740498
SN - 1471-003X
VL - 7
SP - 449
EP - 463
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 6
ER -