In vivo imaging of CNS injury and disease

Katerina Akassoglou, Mario Merlini, Victoria A. Rafalski, Raquel Real, Liang Liang, Yunju Jin, Sarah E. Dougherty, Vincenzo De Paola, David J. Linden, Thomas Misgeld, Binhai Zheng

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


In vivo optical imaging has emerged as a powerful tool with which to study cellular responses to injury and disease in the mammalian CNS. Important new insights have emerged regarding axonal degeneration and regeneration, glial responses and neuro inflammation, changes in the neurovascular unit, and, more recently, neural transplantations. Accompanying a 2017 SfN Mini-Symposium, here, we discuss selected recent advances in understanding the neuronal, glial, and other cellular responses to CNS injury and disease with in vivo imaging of the rodent brain or spinal cord. We anticipate that in vivo optical imaging will continue to be at the forefront of breakthrough discoveries of fundamental mechanisms and therapies for CNS injury and disease.

Original languageEnglish
Pages (from-to)10808-10816
Number of pages9
JournalJournal of Neuroscience
Issue number45
StatePublished - 8 Nov 2017


  • Blood-brain barrier
  • IPSCs
  • Microglia
  • Retina
  • Two-photon imaging


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