In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source

Regine Gradl, Martin Dierolf, Benedikt Günther, Lorenz Hehn, Winfried Möller, David Kutschke, Lin Yang, Martin Donnelley, Rhiannon Murrie, Alexander Erl, Tobias Stoeger, Bernhard Gleich, Klaus Achterhold, Otmar Schmid, Franz Pfeiffer, Kaye Susannah Morgan

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.

Original languageEnglish
Article number6788
JournalScientific Reports
Issue number1
StatePublished - 1 Dec 2018


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