In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source

Regine Gradl; Martin Dierolf; Benedikt Günther; Lorenz Hehn; Winfried Möller; David Kutschke; Lin Yang; Martin Donnelley; Rhiannon Murrie; Alexander Erl; Tobias Stoeger; Bernhard Gleich; Klaus Achterhold; Otmar Schmid; Franz Pfeiffer; Kaye Susannah Morgan

doi:10.1038/s41598-018-24763-8

In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source

Regine Gradl, Martin Dierolf, Benedikt Günther, Lorenz Hehn, Winfried Möller, David Kutschke, Lin Yang, Martin Donnelley, Rhiannon Murrie, Alexander Erl, Tobias Stoeger, Bernhard Gleich, Klaus Achterhold, Otmar Schmid, Franz Pfeiffer, Kaye Susannah Morgan

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31 Scopus citations

Abstract

We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.

Original language	English
Article number	6788
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-24763-8
State	Published - 1 Dec 2018

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abstract = "We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.",

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AU - Gradl, Regine

AU - Dierolf, Martin

AU - Günther, Benedikt

AU - Hehn, Lorenz

AU - Möller, Winfried

AU - Kutschke, David

AU - Yang, Lin

AU - Donnelley, Martin

AU - Murrie, Rhiannon

AU - Erl, Alexander

AU - Stoeger, Tobias

AU - Gleich, Bernhard

AU - Achterhold, Klaus

AU - Schmid, Otmar

AU - Pfeiffer, Franz

AU - Morgan, Kaye Susannah

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AB - We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.

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In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source

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