In vivo assessment of rat hearts with and without myocardial infarction by cine NMR - comparison of the NMR method to invasive techniques and application to intervention studies

M. Nahrendorf, K. H. Hiller, K. Hu, C. Waller, F. Wiesmann, J. Ruff, G. Ertl, A. Haase, W. R. Bauer

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Aim of the study was to test the feasibility of cine-NMR for assessment of the infarcted rat heart and to compare the results to established methods. Thereafter, the value of cine-NMR was tested in studies investigating interventions to change the course of the remodeling process. NMR was performed for determination of left ventricular (LV) volumes and mass, MI-size and cardiac output. After MRI rats underwent conventional hemodynamic measurements for determination of cardiac output and LV volumes by electromagnetic flowmeter and pressure-volume curves. LV wet weight was determined. MI-size was determined by histology. MRIacquired MI-size (18.5 ± 2%) was smaller than histology (22.8 ± 2.5%, p < 0.05) with close correlation (r = 0.97). There was agreement in LV mass between MRI and wet weight (r = 0.97, p < 0.05) and in the MRI- and flowmeter measurements of cardiac output (r = 0.80, p < 0.05). Volume by MRI differed from pressure-volume curves with good correlation (r = 0.96, p < 0.05). In conclusion, cine-NMR is a valuable diagnostic tool applicable to the rat model of MI. Being non-invasive and exact it offers new insights in the remodeling process after MI because serial measurements are possible.

Original languageEnglish
Title of host publicationFunctional Imaging and Modeling of the Heart - 1st International Workshop, FIMH 2001, Proceedings
EditorsToivo Katila, Jukka Nenonen, Isabelle E. Magnin, Patrick Clarysse, Johan Montagnat
PublisherSpringer Verlag
Pages97-103
Number of pages7
ISBN (Print)3540428615, 9783540428619
DOIs
StatePublished - 2001
Externally publishedYes
Event1st International Workshop on Functional Imaging and Modeling of the Heart, FIMH 2001 - Helsinki, Finland
Duration: 15 Nov 200116 Nov 2001

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume2230
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Workshop on Functional Imaging and Modeling of the Heart, FIMH 2001
Country/TerritoryFinland
CityHelsinki
Period15/11/0116/11/01

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