In vitro transformation of the tremorgenic mycotoxin verruculogen

A. Bott, J. Bauer, M. Gareis, C. Enders, B. Kollarczik, B. Gedek

Research output: Contribution to journalArticlepeer-review

Abstract

A quantity of 50 mg of crystalline verruculogen was prepared from batch cultures of Aspergillus fumigatus for the use in the in vitro studies with S-9 liver fractions, feces suspensions, and cultures of Escherichia coli. Incubation of verruculogen with S-9 liver fractions from swine resulted in the transformation of the parent compound into TR-2 toxin and 3 other more polar. TR-2 toxin was also shown to be the main transformation product when incubat-ing verruculogen with fecal suspensions or pure cultures of E. coli (0149: K88). Incubation times of more than 2 hours led to a complete degradation of verruculogen as well as TR -2 toxin.

Original languageEnglish
Pages (from-to)2-8
Number of pages7
JournalMycotoxin Research
Volume8
Issue number1
DOIs
StatePublished - Mar 1992
Externally publishedYes

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