In vitro exposure systems and bioassays for the assessment of toxicity of nanoparticles to the human lung

Hanns R. Paur, S. Mülhopt, C. Weiss, S. Diabaté

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The rapid development of nanotechnology requires the production of nanoparticles which are found in numerous novel products. To reduce the number of animal tests during the assessment of lung toxicity of airborne nanoparticles in vitro exposure systems and lung specific bioassays have been developed. The reproducible application of bioassays for exposure of lung cells at the air-liquid interface promises a higher efficiency and cost reductions in toxicological testing. Despite significant progress of the exposure technology and fundamentals of bioassays a stringent validation of the in vitro versus in vivo tests is still lacking.

Original languageEnglish
Pages (from-to)319-329
Number of pages11
JournalJournal fur Verbraucherschutz und Lebensmittelsicherheit
Volume3
Issue number3
DOIs
StatePublished - Aug 2008
Externally publishedYes

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