In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles

Christoph Alexiou; Roland Jurgons; Roswitha Schmid; Andrea Hilpert; Christian Bergemann; Fritz Parak; Heinrich Iro

doi:10.1016/j.jmmm.2005.02.036

In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles

Christoph Alexiou, Roland Jurgons, Roswitha Schmid, Andrea Hilpert, Christian Bergemann, Fritz Parak, Heinrich Iro

Chair of Biomedical Physics

Research output: Contribution to journal › Article › peer-review

173 Scopus citations

Abstract

Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy.

Original language	English
Pages (from-to)	389-393
Number of pages	5
Journal	Journal of Magnetism and Magnetic Materials
Volume	293
Issue number	1
DOIs	https://doi.org/10.1016/j.jmmm.2005.02.036
State	Published - May 2005

Keywords

Cancer treatment
Chemotherapy
Ferrofluids
HeLa cells
Magnetic drug targeting
Mitoxantrone
Nanoparticles
VX2 Tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jmmm.2005.02.036

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title = "In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles",

abstract = "Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy.",

keywords = "Cancer treatment, Chemotherapy, Ferrofluids, HeLa cells, Magnetic drug targeting, Mitoxantrone, Nanoparticles, VX2 Tumor",

author = "Christoph Alexiou and Roland Jurgons and Roswitha Schmid and Andrea Hilpert and Christian Bergemann and Fritz Parak and Heinrich Iro",

note = "Funding Information: This study was supported by DFG-SPP 1104 AL 552/2-2, Margarete-Ammon Foundation, Munich and ELAN-Fonds AZ03.05.241.",

year = "2005",

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doi = "10.1016/j.jmmm.2005.02.036",

language = "English",

volume = "293",

pages = "389--393",

journal = "Journal of Magnetism and Magnetic Materials",

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TY - JOUR

T1 - In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles

AU - Alexiou, Christoph

AU - Jurgons, Roland

AU - Schmid, Roswitha

AU - Hilpert, Andrea

AU - Bergemann, Christian

AU - Parak, Fritz

AU - Iro, Heinrich

N1 - Funding Information: This study was supported by DFG-SPP 1104 AL 552/2-2, Margarete-Ammon Foundation, Munich and ELAN-Fonds AZ03.05.241.

PY - 2005/5

Y1 - 2005/5

N2 - Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy.

AB - Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy.

KW - Cancer treatment

KW - Chemotherapy

KW - Ferrofluids

KW - HeLa cells

KW - Magnetic drug targeting

KW - Mitoxantrone

KW - Nanoparticles

KW - VX2 Tumor

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DO - 10.1016/j.jmmm.2005.02.036

M3 - Article

AN - SCOPUS:18144386157

SN - 0304-8853

VL - 293

SP - 389

EP - 393

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 1

ER -

In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles

Abstract

Keywords

UN SDGs

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