In case of stress, hold tight: phosphorylation switches PDI from an oxidoreductase to a holdase, tuning ER proteostasis

Joao P.L. Coelho, Matthias J. Feige

Research output: Contribution to journalComment/debate

Abstract

Eukaryotic cells have evolved multiple responses that allow endoplasmic reticulum (ER) homeostasis to be maintained even in the face of acute or chronic stresses. In this issue, Yu et al (2020) describe how site-specific phosphorylation switches protein disulfide isomerase (PDI) from a folding enzyme to a holdase chaperone which regulates ER stress responses, thus highlighting PDI as a key player in ER homeostasis.

Original languageEnglish
Article numbere104880
JournalEMBO Journal
Volume39
Issue number10
DOIs
StatePublished - 18 May 2020

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