Improved cerebral vasoreactivity after statin administration in healthy adults

Background and Purpose. Significant improvements of cerebral vasomotor reactivity during statin treatment were found in patients with cerebral small-vessel disease. The authors analyzed the cerebrovascular CO₂ reactivity before and after statin administration in healthy adults using a case-control study design. Methods. The mean cerebral blood flow velocity (CBFV) of both middle cerebral arteries and the vasomotor reserve capacity (VMRC) were measured by repeated and simultaneous bilateral transcranial Doppler sonography in 25 healthy adults (7 men, mean age 28.8 years [95% confidence interval (CI): 25.7; 31.9]) before, during (days 1, 3, 7, and 14), and after administration of 40 mg pravastatin for 14 days as compared to 10 healthy control persons (4 men, mean age 30.6 years [95% CI: 22.9; 38.3]). The VMRC was calculated off-line as the percentage change of CBFV per 1% increase in end-tidal CO₂ by a blinded investigator. Results. In the statin group, 5 persons were excluded from further analysis, In the remaining 20 volunteers, the authors observed a highly significant effect of statin administration on VMRC (P = .002). The VMRC was significantly increased after statin administration on day 7 as compared to the initial value (3.03 [95% CI: 2.67; 3.38] vs 2.64 [95% CI: 2.41; 2.86]; P = .04). The effect was most pronounced in patients with lower initial VMRC values. In the control group, the VMRC did not differ significantly from baseline at different time intervals, Conclusions. The findings indicate an improvement of cerebral vasoreactivity even after short-term statin administration in healthy adults. However, this effect was related to baseline vasoreactivity.