Impact of the SARS-CoV-2 pandemic on the survival of patients with high-grade glioma and best practice recommendations

Marco M.E. Vogel, Arthur Wagner, Jens Gempt, Harald Krenzlin, Thomas Zeyen, Richard Drexler, Martin Voss, Charlotte Nettekoven, Tammam Abboud, Dorothee Mielke, Veit Rohde, Marco Timmer, Roland Goldbrunner, Joachim P. Steinbach, Lasse Dührsen, Manfred Westphal, Ulrich Herrlinger, Florian Ringel, Bernhard Meyer, Stephanie E. Combs

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has changed the clinical day-to-day practice. The aim of this study was to evaluate the impact of the pandemic on patients with high-grade glioma (HGG) as well as to derive best practice recommendations. We compared a multi-institutional cohort with HGG (n = 251) from 03/2020 to 05/2020 (n = 119) to a historical cohort from 03/2019 to 05/2019 (n = 132). The endpoints were outcome (progression-free survival (PFS) and overall survival (OS)) as well as patterns of care and time intervals between treatment steps. The median OS for WHO grade 4 gliomas was 12 months in 2019 (95% Confidence Interval 9.7–14.3 months), and not reached in 2020 (p =.026). There were no other significant differences in the Kaplan–Meier estimates for OS and PFS between cohorts of 2019 and 2020, neither did stratification by WHO grade reveal any significant differences for OS, PFS or for patterns of care. The time interval between cranial magnetic resonance imaging (cMRI) and biopsy was significantly longer in 2020 cohort (11 versus 21 days, p =.031). Median follow-up was 10 months (range 0–30 months). Despite necessary disease containment policies, it is crucial to ensure that patients with HGG are treated in line with the recent guidelines and standard of care (SOC) algorithms. Therefore, we strongly suggest pursuing no changes to SOC treatment, a timely diagnosis and treatment with short time intervals between first symptoms, initial diagnosis, and treatment, as well as a guideline-based cMRI follow-up.

Original languageEnglish
Article number2766
JournalScientific Reports
Issue number1
StatePublished - Dec 2023
Externally publishedYes


Dive into the research topics of 'Impact of the SARS-CoV-2 pandemic on the survival of patients with high-grade glioma and best practice recommendations'. Together they form a unique fingerprint.

Cite this