Impact of stent strut design in metallic stents and biodegradable scaffolds

Nicolas Foin, Renick D. Lee, Ryo Torii, Juan Luis Guitierrez-Chico, Alessio Mattesini, Sukhjinder Nijjer, Sayan Sen, Ricardo Petraco, Justin E. Davies, Carlo Di Mario, Michael Joner, Renu Virmani, Philip Wong

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations

Abstract

Advances in the understanding of healing mechanisms after stent implantation have led to the recognition of stent strut thickness as an essential factor affecting re-endothelialization and overall long term vessel healing response after Percutaneous Coronary Interventions (PCI). Emergence of Drug-eluting stents (DESs) with anti-proliferative coating has contributed to reducing the incidence of restenosis and Target Lesion Revascularization (TVR), while progress and innovations in stent materials have in the meantime facilitated the design of newer platforms with more conformability and thinner struts, producing lesser injury and improving integration into the vessel wall. Recent advances in biodegradable metal and polymer materials now also allow for the design of fully biodegradable platforms, which are aimed at scaffolding the vessel only temporarily to prevent recoil and constrictive remodeling of the vessel during the initial period required, and are then progressively resorbed thereby avoiding the drawback of leaving an unnecessary implant permanently in the vessel. The aim of this article is to review recent evolution in stent material and stent strut design while understanding their impact on PCI outcomes. The article describes the different metallic alloys and biodegradable material properties and how these have impacted the evolution of stent strut thickness and ultimately outcomes in patients.

Original languageEnglish
Pages (from-to)800-808
Number of pages9
JournalInternational Journal of Cardiology
Volume177
Issue number3
DOIs
StatePublished - 20 Dec 2014
Externally publishedYes

Keywords

  • Bioabsorbable scaffolds
  • DES
  • Neointimal coverage
  • PCI
  • Re-endothelialization
  • Strut thickness

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