Impact of pathologic complete response on disease-free survival in patients with esophagogastric adenocarcinoma receiving preoperative docetaxel-based chemotherapy

S. Lorenzen, P. Thuss-Patience, S. E. Al-Batran, F. Lordick, B. Haller, T. Schuster, C. Pauligk, K. Luley, D. Bichev, G. Schumacher, N. Homann

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Background: The aim of this study was to evaluate the impact of pathologic complete response (pCR) on outcome in patients with gastric or esophagogastric junction (EGJ) adenocarcinoma after neoadjuvant docetaxel/platin/fluoropyrimidine-based chemotherapy.Patients and methods: Patients received at least one cycle of chemotherapy for potentially operable disease.Pretreatment clinicopathologic factors and pCR were investigated. Disease-free survival (DFS), overall survival (OS) and tumor-related death were correlated with pCR.Results: One hundred twenty patients were included in this analysis. Eighteen patients (15%) achieved a pCR. Tumor localization in the EGJ was identified as the only significant predictor of pCR (P = 0.019). Median follow-up was 41.1 months. Median DFS and OS for all patients were 24.1 and 48.6 months, respectively. Median DFS for patients with a pCR was not reached versus 22.1 months non-pCR patients (hazard ratio, HR 0.38; 3-year DFS: 71.8% and 37.7%,respectively, P = 0.018). While OS was not significantly different, the risk for tumor-related death was significantly lower for pCR patients compared with non-pCR patients (3-year cumulative incidences of 6.4% and 45.4%, respectively, P=0.009). Conclusion: A pCR following preoperative docetaxel/platin/fluoropyrimidine indicates favorable outcome in patients with gastric or EGJ adenocarcinoma. Tumor location in the EGJ is associated with a higher pCR rate.

Original languageEnglish
Pages (from-to)2068-2073
Number of pages6
JournalAnnals of Oncology
Volume24
Issue number8
DOIs
StatePublished - Aug 2013
Externally publishedYes

Keywords

  • Docetaxel
  • Esophagogastric adenocarcinoma
  • Pathologic complete response
  • Preoperative

Fingerprint

Dive into the research topics of 'Impact of pathologic complete response on disease-free survival in patients with esophagogastric adenocarcinoma receiving preoperative docetaxel-based chemotherapy'. Together they form a unique fingerprint.

Cite this